Hello. My name is Ana Fernandez-Sesma.
I am a Professor in
the Department of Microbiology at Icahn School of Medicine at Mount Sinai in New York.
And today, I'm going to talk about Dengue, Zika,
and Chickungunya viruses and some important background information,
as well as how we believe they're really able to
deal within our immunity in infected cells.
First, I want to introduce the concept of
Arboviruses since there's really not a classification,
but its basically referred to
Arthropod Borne viruses and there are several families and genera that belong to
these classification of Arboviruses and it includes
the Togaviridae and Flaviviridae in particular.
And today, we're going to talk about Alphaviruses,
which include different viruses such as
Equine Eastern Encephalitis, Western Equine Encephalitis,
and Venezuelan Eastern Encephalitis that as the name indicates cause encephalitis,
but also includes the infamous virus,
Chickungunya virus that has caused some epidemics in the recent years,
and that can cause febrile disease,
and chronic arthritis in humans.
Then it also includes a family of
Flaviviridae that are all both, Togaviridae and Flaviviridae,
at single strand positive RNA viruses and
the Flaviviruses includes several known pathogens of humans such as West Nile virus,
Japanese Encephalitis, St. Louis Encephalitis that they are causing encephalitis,
then yellow fever virus that cause liver disease,
and also Dengue, and Zika viruses.
Dengue is most known for causing these febrile disease and
Dengue hemorrhagic fever and we will talk a little bit in detail about these virus.
And then Zika virus has been more notorious in the last year because it caused
febrile disease. It had
this severe association of fetal brain damage in infected pregnant women.