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1. Introduction
2. Topics to be covered
3. Rationales for the study of Poxviruses
4. Poxvirus taxonomy
5. Poxvirus life cycle
6. Chromosome organization
7. The terminal region of the chromosome
8. Virion structure
9. Virus entry
10. Viral proteins needed for entry
11. Mechanism of EV entry
12. Gene expression
13. Temporal profile of gene expression
14. Early gene transcription
15. Intermediate and late gene transcription
16. Working model of DNA replication
17. The Poxvirus replication apparatus
18. Schematic of the core replication apparatus
19. Intracellular localization of genome replication
20. Schematic of Poxvirus morphogenesis
21. EM image of Poxvirus morphogenesis
22. Key features of early morphogenesis
23. Visualization of the D13 lattice
24. Key features of the IV to MV transition
25. Poxvirus-mediated disulfide bond formation
26. Formation of extracellular virions
27. Vaccinia virus egress
28. Mechanism of EV release and spread
29. Cytopathic effects of Orthopoxvirus infection
30. Repertoire of Poxvirus immunomodulators
31. Immunomodulators and disease
32. Animal models of Poxvirus infection
33. Smallpox - epidemiology
34. Smallpox disease
35. Vaccinia vs. Variola
36. Poxvirus vaccination
37. WHO smallpox recognition card
38. Declaration of smallpox eradication
39. Monkeypoxvirus
40. Antipoxvirus therapy
41. Rationale for the experimental study of Poxviruses
42. Figure citations

Topics Covered

• Poxvirus life cycle: chromosome structure, virion structure and virion entry
• Viral proteins needed for entry and mechanism of entry of EV (enveloped virion)
• Gene expression of EV: early transcription, intermediate and late transcription
• Working model of Poxvirus genome replication
• Morphogenesis of EV
• Key features of the IV to MV (mature virions) transition
• Poxviruses encode a three-protein complex that generates disulfide bonds in the cytoplasm
• Formation of EEV (extracellular enveloped virions) and EV mediators of cell-to-cell and distal spread
• Poxviruses encode a large array of immunomodulators
• Models for the study of Poxvirus pathogenesis
• Smallpox (Variola virus) and smallpox disease
• Pathogenicity of Variola virus vs. Vaccinia virus
• Official declaration of the eradication of smallpox
• Monkeypox virus
• Antiviral therapy and new vaccines for Poxviruses

Links

Series:

• Viruses and Viral Diseases

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Traktman, P. (2007, October 1). Poxviruses: smallpox (variola), vaccinia and monkeypox [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/TUGX7084.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on December 31, 2017

Financial Disclosures

• Prof. Paula Traktman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.