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- General Virology
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1. Principles of virology
- Prof. Vincent Racaniello
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2. The type I interferon system and viruses
- Dr. Adolfo Garcia-Sastre
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3. Immune responses to viruses
- Prof. Paul Klenerman
- Emerging Pathogens
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4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide
- Dr. Marietjie Venter
- Mrs. Orienka Hellferscee
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5. Emerging respiratory viruses - discoveries between 2001 and 2005
- Prof. Ron Fouchier
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6. Usage of vaccines and therapeutics in public health emergencies 1
- Prof. Gary Kobinger
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7. Usage of vaccines and therapeutics in public health emergencies 2
- Prof. Gary Kobinger
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8. Influenza virus pandemics: past and future
- Prof. Peter Palese
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9. SARS-CoV and other emerging coronaviruses
- Prof. Ralph Baric
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10. Dengue, Zika and Chickungunya viruses
- Prof. Ana Fernandez-Sesma
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11. Paramyxoviruses: biology & pathogenesis
- Prof. Benhur Lee
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12. Antiviral drugs (non-HIV)
- Prof. Megan Shaw
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13. Biodefense challenges
- Dr. David Franz
- Important Pathogens and their Diseases
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14. Natural history and pathogenesis of herpes virus infections
- Prof. Richard Whitley
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15. Cytomegalovirus biology
- Prof. Domenico Tortorella
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16. Hepatitis C virus: discovery, cure and protection
- Dr. Matthew Evans
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17. Fundamentals of HIV biology
- Prof. Viviana Simon
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18. Measles
- Prof. Diane E. Griffin
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19. Monkeypox virus, vaccines, and therapeutics
- Prof. Rachel Roper
- New Frontiers
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22. Viruses as anticancer weapons
- Prof. Roberto Cattaneo
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23. Novel approaches to diagnosis of viral infections
- Prof. W. Ian Lipkin
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24. The Global Virus Network: collaboration to address pandemic and regional threats
- Prof. Sten H. Vermund
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25. Elite controllers of HIV: from discovery to future therapies
- Prof. Bruce Walker
- Archived Lectures *These may not cover the latest advances in the field
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26. Principles of virology I
- Prof. Richard Condit
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27. Principles of virology II
- Prof. Richard Condit
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28. Complex DNA viruses: herpes virus
- Dr. John Blaho
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29. Adeno-associated viruses (AAV)
- Prof. Kenneth Berns
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30. Poxviruses: smallpox (variola), vaccinia and monkeypox
- Prof. Paula Traktman
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31. Can HPV testing be the sole primary cervical screening modality?
- Prof. Jack Cuzick
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32. From viruses to oncolytics
- Prof. Roberto Cattaneo
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33. Non HIV antivirals
- Prof. Mary Klotman
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34. Gastroenteritis viruses
- Prof. Mary Estes
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35. Biodefense challenges
- Dr. Connie Schmaljohn
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37. The past, present and future of vaccination
- Prof. Stanley Plotkin
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38. Filoviruses
- Dr. Christopher Basler
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39. Bunyaviruses
- Prof. Richard Elliott
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40. The immunobiology of HIV
- Prof. Norman Letvin
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41. Hepatitis C and HCV
- Prof. Stanley Lemon
Printable Handouts
Navigable Slide Index
- Introduction
- SARS-CoV and other emerging coronavirus
- Nidovirales family
- Nidovirales order
- coronavirus phylogeny
- Emerging coronaviruses: timeline
- SARS-CoV 2002
- SARS-CoV timline: superspreading events
- International travel (daily)
- MERS-CoV 2012 (1)
- MERS-CoV 2012 (2)
- ARDS- acute respiratory distress syndrome
- Virus particle and entry coronavirus emergence
- Coronavirus virion structure
- MERS- CoV (1)
- MERS- CoV (2)
- MERS- CoV (3)
- Mechanism of CoV emergence
- Cell surface receptors and virus entry
- Cell receptor: role in emergence
- Public health preparedness: is SARS extinct
- Prepandemic group: entry
- How to test prepandemic potential?
- Chimeric SARS-like viruses
- Virus strains
- Emerging CoV pandemic preparedness
- Virus gene organization and replication cycle
- SARS genome organization
- Coronavirus genome organization
- CoV docking and virus entry
- SARS-CoV receptor
- Coronaviruses replicate and cause disease
- SARS coronavirus ORF1 processing (1)
- SARS coronavirus ORF1 processing (2)
- SARS coronavirus ORF1 processing (3)
- SARS coronavirus ORF1 processing (4)
- SARS coronavirus ORF1 processing (5)
- SARS coronavirus ORF1 processing (6)
- ORF1 replicase protein function
- ORF1B replicase function
- SARS group specific genes (1)
- SARS group specific genes (2)
- SARS genome replication (1)
- SARS genome replication (2)
- SARS genome replication (3)
- SARS genome replication (4)
- SARS genome replication (5)
- SARS genome replication (6)
- How to synthesize subgenomic mRNA?
- SARS subgenomic transcription (1)
- SARS subgenomic transcription (2)
- SARS subgenomic transcription (3)
- SARS subgenomic transcription (4)
- SARS subgenomic transcription (5)
- SARS subgenomic transcription (6)
- SARS subgenomic transcription (7)
- SARS subgenomic transcription (8)
- Nidovirus transcription
- Egress
- Current status: antiviral therapies
- GS-5734 is a broad-spectrum antiviral
- GS-5734 is a monophosphoramidate prodrug
- Efficacy of GS-5734 against diverse CoV
- GS-5734 diminishes SARS-CoV disese in vivo
- Summary
- References (1)
- References (2)
- References (3)
Topics Covered
- Nidovirales family
- Coronavirus phylogeny
- Timeline of emerging coronaviruses
- Virus particles and entrance
- Coronavirus structure
- MERS-CoV group 2c betacoronavirus
- Mechanisms of CoV emergence
- Role of cell surface receptors
- Public health preparedness
- Is SARS extinct?
- Pre-pandemic group 2b SARS-like bat coronaviruses
- How to test pre-pandemic potential
- Virus gene organization and replication cycle
- How do coronaviruses cause disease
- SARS coronavirus ORF1 processing
- ORF1B replicase function
- SARS genome replication
- SARS sub-genomic transcription
- Current antiviral therapies
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Baric, R. (2018, November 28). SARS-CoV and other emerging coronaviruses [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/RODR2141.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ralph Baric has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Microbiology
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Ralph Baric. I'm a professor in epidemiology
and microbiology and immunology at the University of North Carolina at Chapel Hill.
I've studied coronaviruses for 30 years.
Now, this presentation will focus on SARS coronavirus and other emerging coronaviruses,
discussing their structure, where they come from,
how they replicate, and how they cause disease.
0:27
And this first slide basically shows electron micrographs of
two of the most notable coronaviruses that the public has heard about.
The SARS coronavirus which was associated with a large epidemic in
2003 is on the left and MERS coronavirus is shown on the right.
Both of these viruses have the capability of causing
high morbidity and mortality in human populations and
causing economic chaos as evidenced by
this quote from the Prime Minister of Singapore during the SARS epidemic,
where he talked about the impact of the SARS epidemic on the economy of Singapore.
During this epidemic, the economic losses worldwide were thought to approach $40 billion.
1:09
So, to start at the beginning,
I want to discuss the nidovirales family.
Both SARS and MERS are members of the nidovirales family.
These are a large group of animal viruses. They are enveloped.
They have a lipid bilayer.
They have the large positive polarity single-stranded RNA virus genomes.
The genome is in the form of a nested set which I'll discuss in more detail later.
There are four genus: the arteriviruses,
the coronaviruses, the mesoniviridae, and the roniviradae.
So, today's talk really focuses exclusively on
the coronoviradae which are further divided into the alpha coronaviruses,
the beta coronaviruses, and the gamma coronaviruses.
And our talk will focus on the beta coronaviruses which are then further broken into the 2a, the
2b, and the 2c, and the 2d.
SARS coronavirus is a member of the 2b coronaviruses,
and MERS coronavirus is a member of the 2c coronaviruses.