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Printable Handouts
Navigable Slide Index
- Introduction
- Timeline of new therapies approved for lymphoma
- Examples of drugs in development for lymphoma
- Novel agents in acute myeloid leukemia
- Novel agents in lymphoma
- Type II monoclonal antibodies (mab's)
- GADOLIN study (design)
- GADOLIN study (results)
- GALLIUM study
- Antibody-drug conjugates for cancer therapy
- Brentuximab vedotin: antibody drug conjugate
- Hodgkin lymphoma
- Phase II study of brentuximab vedotin
- 5-year survival & durability of brentuximab vedotin
- Response in relapsed T cell lymphomas
- Brentuximab: mycosis fungoids, Sezary syndrome
- Bortezomib: proteasome inhibition
- Multicenter phase II study of bortezomib
- Bortezomib-based therapy
- HDAC inhibitors in PTCL/CTCL
- Belinostat in patients with R/R PTCL: BELIEF trial
- Phase II results of HDAC inhibitors in R/R PTCL
Topics Covered
- Lymphoma and leukemia
- Treatment of non-Hodgkin & Hodgkin lymphoma
- Novel targeted agents in B and T-cell lymphoma (antibody–drug conjugates)
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Reddy, N.M. (2017, May 29). Novel treatment options in lymphoma and leukemia 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2019, from https://hstalks.com/bs/3515/.Publication History
Financial Disclosures
- Prof. Nishitha M. Reddy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Novel treatment options in lymphoma and leukemia 1
Published on May 29, 2017
32 min
Other Talks in the Series: Cancer Therapies in the Personalized Medicine Era
Transcript
0:00
Hello everyone.
My name is Nishitha Reddy
and I'm the Associate Professor
of Medicine
at Vanderbilt University Medical Center
and the Director
of the Lymphoma Program here.
Today we'll be discussing
the novel treatment options
that are available for lymphoma
and leukemia treatments.
0:19
So in the last decade, we have seen
an emergence of several new drugs
that have been approved for both Hodgkin
and non-Hodgkin lymphoma,
and most of these agents
are targeted therapies
that were designed
to alter a specific pathway
or antibodies
that bind to a particular site.
As we can see here,
several novel agents have been approved
since 2008 up until now.
Starting in 2008,
bendamustine was approved
for relapsed indolent lymphomas.
And following that,
several new agents have been
approved specifically obinutuzumab,
which is one of the novel
monoclonal antibody therapies
for approval in CLL
and relapsed follicular lymphoma
in combination with bendamustine.
Another agent is brentuximab,
which was approved in 2011
for Hodgkin lymphoma.
And more recently
some of the novel agents
such as PD-1 inhibitors,
specifically nivolumab and pembrolizumab
have been given accelerated approval
for Hodgkin lymphoma.
So in the next several slides,
we will be discussing the mechanisms
of action of these agents,
the current indications,
the side effects of novel agents
used in the treatment of lymphomas
and leukemias.