Hello. I'm Jill Kolesar.
Today we're going to talk about
the second part of the lecture
which is the pharmacodynamics
of anticancer agents.
So let's move on to pharmacodynamics
which is what the drug does to the body.
So in pharmacodynamics,
we draw a different type of curve
and this is concentration
versus effect curve.
And so in this diagram, you can see
concentration is going to be
on the X-axis
so that's concentration in plasma.
And then we look at effect
and that's going to be on the Y-axis.
So what you can see
from this slide that, you know,
way to the very left of the diagram
where the concentration is low,
they'll have little effect,
and then what we would like
to see with drugs,
so this is kind of
an ideal concentration
versus effect slide
that we have a linear relationship
between concentration and effect.
So you can see that
in a more linear part of the curve
and then typically
you reach plateau effect
as the concentration goes higher,
you don't get a higher effect.
So this is the typical diagram
for drug-receptor interactions.
Drugs typically act
by binding to receptors
and they may activate
or inactivate them.
It's also a mechanism of action
for anticancer agents
and what we really looking for here
is a dose response relationships.