Overview of clinical pharmacology in cancer 2

Published on May 29, 2017   18 min
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Hello. I'm Jill Kolesar. Today we're going to talk about the second part of the lecture which is the pharmacodynamics of anticancer agents.
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So let's move on to pharmacodynamics which is what the drug does to the body. So in pharmacodynamics, we draw a different type of curve and this is concentration versus effect curve. And so in this diagram, you can see concentration is going to be on the X-axis so that's concentration in plasma. And then we look at effect and that's going to be on the Y-axis. So what you can see from this slide that, you know, way to the very left of the diagram where the concentration is low, they'll have little effect, and then what we would like to see with drugs, so this is kind of an ideal concentration versus effect slide that we have a linear relationship between concentration and effect. So you can see that in a more linear part of the curve and then typically you reach plateau effect where even as the concentration goes higher, you don't get a higher effect. So this is the typical diagram for drug-receptor interactions. Drugs typically act by binding to receptors and they may activate or inactivate them. It's also a mechanism of action for anticancer agents and what we really looking for here is a dose response relationships.