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Navigable Slide Index

1. Introduction
2. Parkinson's disease (PD)
3. Pathophysiology of PD
4. Clinical manifestations of PD
5. Neuropathology of PD
6. Etiology of PD
7. Genetics of PD
8. Alpha-synuclein
9. Mutations in gene encoding alpha-synuclein
10. Alpha-synuclein - possible toxicity mechanisms
11. Drosophila models of PD and chaperones
12. Mouse genetic model of PD and chaperones
13. Mouse toxic model of PD and chaperones
14. Protective effects of chaperones - explained
15. Hsp70 effect on alpha-synuclein aggregation (1)
16. Hsp70 effect on alpha-synuclein aggregation (2)
17. Model for alpha-synuclein fibrillization pathway
18. Parkin
19. Parkin mutations
20. Parkin inactivation mechanisms (1)
21. Chaperone interference with parkin misfolding
22. Parkin inactivation mechanisms (2)
23. Parkin has an E3 ubiquitin ligase activity
24. Parkin inactivation leads to neuronal death (1)
25. Parkin inactivation leads to neuronal death (2)
26. Summary

Topics Covered

• Parkinson's disease
• Pathophysiology, neuropathology, etiology
• Genes associated with Parkinson's disease
• Role of protein misfolding in Parkinson's disease
• alpha-synuclein: protein misfolding and a gain of toxic function
• Parkin: protein misfolding and a loss of physiological function
• Effect of chaperones in different models of Parkinson's disease

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Winklhofer, K.F. (2007, October 1). The role of chaperones in Parkinson's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/AOZA9523.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Dr. Konstanze F. Winklhofer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.