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Printable Handouts
Navigable Slide Index
- Introduction
- Objectives
- What is a TIA: Definition of TIA
- TIA can be difficult to diagnose: Mimics (30–50%)
- What occurs during a TIA at a cerebral hemodynamic and cellular level?
- MR DWI + lesions are common after “TIA” and are associated with duration of symptoms
- Significance of DWI lesions in TIA patients
- Why is a diagnosis of TIA important: Opportunity to intervene
- TIA/minor stroke patients evaluated by stroke specialists have lower rate of recurrent events
- Cognitive dysfunction following stroke
- Concept of Vascular Cognitive Impairment (VCI)
- Why would a TIA result in cognitive impairment?
- Cognitive impairment following TIA
- What neuropsychological tests should be used to examine cognitive impairment in TIA patients?
- MOCA is useful in detecting MCI at 1-year post-stroke/TIA
- Imaging factors associated with increased risk of cognitive dysfunction following stroke
- Imaging and baseline predictors of cognitive dysfunction in minor stroke and high-risk TIA
- Long term effects of TIA and minor stroke on brain atrophy compared to normal controls
- Does transient brain hypoperfusion lead to structural brain changes in TIA patients?
- Limitations of previous studies
- Future questions and directions
- Summary
Topics Covered
- Definition and explanation of a transient ischemic attack (TIA)
- Stroke and dementia
- Symptoms associated with TIA
- Cognitive dysfunction
- Cognitive deficits and imaging following TIA
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Talk Citation
Mandzia, J. (2021, April 28). Transient ischemic attack and cognition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/LZWC3057.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Jennifer Mandzia.
I'm an assistant professor from Western University,
the Department of Clinical Neurosciences in London,
and the Co-medical Director of the Stroke Program here at
London Health Sciences and in Southwestern Ontario Stroke Network in Canada.
Today I'm going to be talking about transient ischemic attack and cognition.
0:25
The objectives today, I am going to start by
defining what is a transient ischemic attack.
Then I'm going to discuss the relationship between cerebrovascular disease and cognition.
Then I will be discussing how cognition is
affected in patients who have had a transient ischemic attack.
Then last, discussing the factors that can
influence and mediate cognitive dysfunction in TIA.
0:55
So what is a TIA?
A transient ischemic attack was traditionally defined, and somewhat arbitrary,
as a focal cerebral ischemic event of the brain or
the retina with symptoms lasting less than 24 hours.
When I say arbitrary,
the duration was defined quite arbitrarily as less than 24 hours.
However, in 2009, a new definition of
TIA was proposed to improve upon the traditional definition,
especially pertaining to the duration of TIAs,
which typically last between 10 minutes to one hour in duration.
So the new definition proposed was a transient episode of neurological dysfunction, caused by
focal brain or spinal cord or
retinal ischemia without an acute infarction seen on imaging.