0:00
My name is Manu Hegde.
I'm a group leader
at the MRC Laboratory
of Molecular Biology
in Cambridge, England.
And today, I'm going to talk about
Protein Quality Control.
The goal of this lecture
is twofold.
First, I want to introduce you
to the concept
of protein quality control
and tell you a bit about
why it's important.
Second, I want to tell you
not just about what we know
but a little bit about
how quality control processes
are studied experimentally
and how we've come to learn
what we know today.
0:30
A good place to start
for any discussion
on protein quality control
is to consider
how incredibly complex
the inside of a cell is.
So what you're seeing
on this slide right now
is a textbook picture
of the inside of a liver cell,
and this is viewed
by electron microscopy.
And what you can see
is how incredibly compartmentalized
the cell is,
so there are lots
of different compartments
that you can see, for example,
I've labeled
the endoplasmic reticulum in green,
mitochondria in red,
peroxisomes in blue and so forth.
And all of these compartments
have unique complements of proteins
and these proteins of course
give these compartments
their unique functional properties.
