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Fuzzy Theory for Disordered Proteins
by Monika Fuxreiter,
Laboratory of Protein Dynamics,
University of Debrecen, Hungary.
Today, I'm going to discuss
the molecular basis
for the intelligent decision
making of proteins
using the framework of the fuzzy theory.
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All cellular processes are determined
by a vast number of interactions
between many different
kinds of biomolecules,
proteins, nucleic acids,
and small organic substrates.
Molecular organizations
and the synergy
between a variety of interactions
control the response
to the environmental signals.
Characteristics
of the biomolecular assemblies
regulate the biological output,
and ultimately, the healthy
or pathological nature
of a biochemical process.
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Protein interactions
need to be selective for their partners,
which are recognized
and also need to be specific
to the circumstances
where the interactions take place.
Here I show interactions
which are specific to different tissues.
Alternative splicing
can rewire the interaction networks
in different cell types
by alternative inclusion
of the binding elements.
Protein assemblies
must also be specific to the signals
which trigger the contacts
between the molecules.
All interactions
must be tightly regulated
by the environmental conditions
which affect the temporal
and spatial characteristics
and the functional consequences
of the assembly.
