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Printable Handouts
Navigable Slide Index
- Introduction
- Local inflammation and AMD
- Macrophage recruitment
- Macrophages and AMD (1)
- Macrophages and AMD (2)
- Histopathological and ultrastructural features
- Macrophage polarization
- Age and macrophage function
- Mechanism of macrophage polarization in AMD (1)
- Mechanism of macrophage polarization in AMD (2)
- Macrophage subtypes in AMD
- M1 and M2 chemokines in AMD lesions
- M2 in atrophic vs. neovascular AMD lesions (1)
- M2 in atrophic vs. neovascular AMD lesions (2)
- Macrophage and complement
- Basic functions of complement
- Candidate immune genes associated with AMD
- Inflammasomes
- Complement and inflammasomes
- Macrophages and inflammasomes (1)
- Macrophages and inflammasomes (2)
- Macrophages and inflammasomes (3)
- NLRP3, IL-1β & IL-18 in AMD macular lesions
- Summary
- Thank you
Topics Covered
- Recruitment of macrophages
- Changes in macrophages and their functions with age
- Mechanisms of macrophage polarization in AMD
- Macrophages and the complement system in AMD
- The relationship between macrophages and inflammasomes
- Alteration of macrophage activity for immune therapy of AMD
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Chan, C. (2016, October 31). Macrophages in AMD [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 14, 2024, from https://doi.org/10.69645/LTVO8212.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Chi-Chao Chan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Macular Degeneration
Transcript
Please wait while the transcript is being prepared...
0:00
I'm Doctor Chi-Chao Chan.
I've been working in NIH
in the past 33 years,
and I just retired last year.
I am a Scientist Emeritus
at National Eye Institute,
National Institute of Health,
United States.
I'm also a Visiting Professor,
Zhonshan Ophthalmic Center,
Sun Yat-sen University in China.
I'm presenting to you Macrophages in AMD
or age-related macular degeneration.
0:35
And you can see
that the local inflammation
is very important in AMD.
This is from Anderson et al,
they had a review,
now it's six years ago,
and showing you the local inflammation
including genetic susceptibility,
environmental factors,
they all get choroid and retina complex
in the macular degenerative eye disease.
And later, the local inflammation
can produce disease
drusen, and geographic,
or neovascular AMD,
of course, complement
play very important role.
As the eye pathologies
are very interesting
in inflammatory cell,
there's macrophage, microglia,
or resident macrophage, and lymphocytes,
they're all inflammatory cells.
The same type, these inflammatory cells,
they can produce
many inflammatory factors
that include cytokines, chemokines,
complement factors, and inflammasomes.
So we need to see how the macrophage
can be put to the side.