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Printable Handouts
Navigable Slide Index
- Introduction
- 2016 – has the age of precision medicine arrived?
- Precision medicine at an inflection point
- Precision medicine definition
- Precision medicine tools
- Precision medicine born in the genomic age
- Precision medicine to personalized medicine
- Personalized medicine - before the genome age
- A practice with which we (cardiology) are familiar
- Personalized cardiovascular medicine
- Mutation specific therapy - CFTR mutations
- Ivacaftor for G551D mutation
- Targeted cancer therapies
- Genotype - specific therapy in cardiology
- Long QT syndrome genetics
- Genotype-specific treatment in LQTS
- Long QT syndrome subtypes
- LQT1 and LQT2
- LQT3
- Late Na+ channel blocker therapy in LQT3
- Selection of patients for primary prevention ICDs
- NA+ channel polymorphism and arrhythmia
- SCN5A S1103Y association with ICD therapy
- S1103Y SNP predicts ICD therapy
- Improve selection of patients for prevention ICDs
- Move from Mendelian genetics to complex traits
- The path to precision medicine
- Does more information increase precision?
- Coming soon to a clinic near you…
- Variant of uncertain clinical significance (VUS)
- Variant identification does not equal causation
- VUS - prognosis
- Notes of caution some well-known surprises
- More than genetics / genomics
- Personalized to precision medicine
- Precision medicine tools - the ‘omics
- Precision medicine devices
- Precision medicine big data
- Conclusions
Topics Covered
- Precision medicine
- Precision medicine to personalized medicine
- Personalized cardiovascular medicine
- Mutation specific therapy
- CFTR mutations
- Targeted cancer therapies
- Genotype: specific therapy in cardiology
- Long QT syndrome genetics
- Move from Mendelian genetics to complex traits
- Variant of uncertain clinical significance (VUS)
- Precision medicine is aiming for the right drug in the right dose at the right time
Links
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Talk Citation
Pitt, G.S. (2016, June 30). Precision medicine and cardiology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/TIUR2209.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Geoffrey S. Pitt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Geoffrey Pitt.
And the title of my presentation
is "Precision Medicine and Cardiology."
0:09
United States President, Barack Obama,
announced in his State of the Union address in January of 2015
that he was launching an effort to emphasize
a Precision Medicine Initiative
and said that the fruits of such efforts
would be in areas such as cancer and diabetes.
0:27
While investigators have been building
on new genomic technologies for over a decade to bring
precision medicine close practice, this attention from a U.S. President
has greatly increased the focus of many thought leaders,
such as indicated by this highlighted editorial
from the current and former directors
of the National Institutes of Health that soon followed
the president's announcement.
As highlighted in President Obama's address,
a lot of attention for precision medicine
has focused on diabetes and cancer.
But cardiovascular diseases remain the number one killer
in the United States.
Is there a role for precision medicine in cardiology?
My goal today will be to convince you that precision medicine
certainly will affect cardiology.
In fact, while many of the mutation-specific cancer therapies
have received a disproportionate amount of the recent attention
focused on precision medicine,
cardiology has been an unrecognized leader, in my opinion,
in the development in precision medicine,
and will continue to do so.
1:26
So first, let me set the stage.
What exactly is precision in medicine?
In this slide you will see several different definitions.
Clearly, if looking at all of these, the concept of precision medicine is fluid.
But the general theme captured by all of these definitions
is that as clinicians our ultimate goal is to treat our patients individually,
aiming for the right drug in the right dose
at the right time.