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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Anatomy and function of conjunctiva
- Diseases of the conjunctiva
- Ocular scarring: huge unmet need worldwide
- Conjunctival scarring after glaucoma surgery
- Scarring causes failure of surgery: blindness
- Phases of wound healing
- Conjunctival wound healing pathways (1)
- Conjunctival wound healing pathways (2)
- Formation of scar tissue
- Mediators of scarring
- Wound healing modulating agents
- Preventing scarring - anti-cancer agents
- Single short applications of antimetabolites
- Local effects, cell death with Mitomycin-C
- Model of successful translational research
- Clinical observation and laboratory research
- Moorfields safer surgery system
- Marked improvement, changing ‘biomechanics’ (1)
- Marked improvement, changing ‘biomechanics’ (2)
- International collaborations: single application 5-FU
- Collaborative studies: Kenyan Study
- Post-operative failure, vascularity and inflammation
- Contraction in the presence of inflammatory cells
- Matrix fibroblasts with and w/o inflammatory cells
- Persistent inflammation reduces efficacy of drugs
- Revisiting inflammation
- Inflammatory receptors and novel drug delivery
- Pain receptors and inflammation
- Modifying extracellular matrix, molecular methods
- MMP modulation- ‘normal’ blebs, minimal scarring
- Scarring, IOP and glaucoma progression
- The future: patient tailored treatment
- Glaucoma: the global challenge & advocacy
- NEI audacious goals, the 10: 10: 10 challenge
- Conjunctival scarring & ocular scarring
Topics Covered
- The anatomy and role of the conjunctiva tissue
- Diseases of the conjunctiva
- Conjunctival scarring
- Phases of wound healing
- Mediators of scarring
- Conjunctival wound healing pathways
- Wound healing modulating agents
- Future prospects for improving outcomes of conjunctival scarring
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Khaw, P. and Sharma, G. (2016, May 31). The conjunctiva and scarring [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/LDER4302.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Sir Peng Khaw has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Ms. Garima Sharma has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Biology of the Eye
Transcript
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0:00
Today, I'm going to talk to you
about the conjunctiva and scarring.
I'm Professor Sir Peng Khaw, and
I'm presenting this to you, together
with Garima Sharma from
Moorfields Eye Hospital
and the University College London
Institute of Ophthalmology.
0:17
Today, we're going to do an overview
of the conjunctiva, the anatomy
and the role of this tissue.
A quick word about some of the
diseases of the conjunctiva,
and then, I'll move into
conjunctival scarring,
the different phases
of wound healing,
the mediators the scarring,
the wound-healing pathways,
how we modulate wound
healing, and then just
a brief word about future prospects
for improving the outcomes
of conjunctival scarring.
0:46
This slide shows the
anatomy and some description
about the function
of the conjunctiva.
Although the conjunctiva
is traditionally
seen just as a covering,
essentially for the eyeball
and the inside of
the eyelids, it has
several very important sections.
There's the bulbar conjunctiva,
which covers the sclera,
the palpebral, which covers the
inner lining of the eyelids,
and, of course, the fornix.
Deep between the two
are the inner reaches
of the eyelid, which
forms the junction
between the eyelid and the eyeball.
The conjunctiva is
extremely important.
Obviously, it forms
a protective layer.
It allows for lubrication
because constantly,
the eyeball and the
eyelids are moving.
And so, therefore, the elements
produced by the conjunctiva are
very, very important in terms
of lubricating and keeping the
conjunctiva and the cornea healthy.
In this diagram, you'll see
various glands which secrete
a fluid and also various important
components such as mucin, which
maintain the multiple
layers of the tear film
and therefore keep the
anterior surface of the cornea
intact, without which the vision
will be severely impaired.
It's important to note that
there's the tarsal plates, which
form the relatively stiff
backbone of the eyelids,
both upper and lower.
And within these lie the meibomian
glands, which secrete the lipid,
which form the outer layer of
the tear film, which prevent
excessive drying of the tear film
and therefore discomfort in people
who have problems with meibomian
gland secretion and inflammation.