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Printable Handouts
Navigable Slide Index
- Introduction
- Congenital aphakia
- Microspherophakia
- Lens duplication
- Lens coloboma
- Lenticonus and lentiglobus
- Posterior lentiglobus
- Posterior lenticonus
- Anterior lenticonus
- Congenital cataract
- Incidence of congenital cataract
- Traditional care pathway
- New algorithm
- Deprivation amblyopia
- Cataract morphology
- Surgery for DENSE congenital cataract
- Cataract surgery
- Infant ocular growth & emmetropisation
- Cataract surgery in infants and young children
- IOL implantation vs. lensectomy
- Advantages of IOL
- IOLUNDER2: results at 1 year
- Factors associated with glaucoma
- Visual Axis Opacification (VAO)
- Why should an IOL be implanted?
- When should an IOL be considered?
- IOL implantation general rules
- Persistent Fetal Vasculature (PFV) a.k.a PHPV
- PFV associations
- Ectopia lentis (lens dislocation)
- Ectopia lentis – common causes
- Marfan Syndrome & Type-1 Fibrillinopathies
- Type-1 fibrillinopathies
- Marfan syndrome (MFS)
- Type-1 fibrillinopathies: lens dislocation
- Homocystinuria
- Weill Marchesani Syndrome (WMS)
- Ectopia Lentis et Pupillae (ELeP)
- Rare causes of ectopia lentis
- Management of ectopia lentis
- Treatment options for ectopia lentis
- Acknowledgements
- Thank you
Topics Covered
- Congenital and developmental lens anomalies including spherophakia, lenticonus and lentiglobus
- Congenital cataract and it’s management
- Lens abnormalities associated with persistent fatal vasculature (PFV)
- Dislocated lenses (Ectopia Lentis): aetiology and management
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Talk Citation
Lloyd, C. (2016, May 31). Lens development and disorders - clinical diagnosis and treatment [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 8, 2024, from https://doi.org/10.69645/KPDG9837.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Chris Lloyd has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Biology of the Eye
Transcript
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0:00
This is the second lecture
dealing with lens development
and lens development disorders.
My name is Professor Chris Lloyd.
I'm a consultant
ophthalmologist at Great
Ormond Street Hospital in London.
I'm also an honorary consultant
at Manchester Royal Eye hospital
and honorary professor of
pediatric ophthalmology
at Manchester Academic
Health Sciences Center
in the University of Manchester.
0:25
Congenital aphakia is an extremely
rare malformation of the eye.
It's usually associated with
other ocular malformations.
It can be caused by
rubella syndrome or
other early teratogenic
influences during the first four
weeks of gestation.
It can be caused by homozygous
mutations in the FOXE3 gene,
as illustrated by the
graphic to the right.
This is a case that was published
in Molecular Vision six years ago.
It can also occur as a
secondary phenomenon due
to persistent fetal vasculature.
1:02
Microspherophakia is
a clinical description
of a spherical lens, a lens that is
reduced in its natural dimensions.
This can be caused by
several conditions.
These include mutations in the LTB2
gene, Weill-Marchesani syndrome,
homocystinuria, and other
pan-ocular disorders,
like Aniridia or
Axenfeld-Rieger syndrome,
which cause damage to the zonule.
1:31
Lens duplication is
also extremely rare.
It's associated with
corneal metaplasia,
uveal coloboma, and cornea plana,
or flattening of the cornea.
It's presumed to be due to
abnormal lens placode formation.
The case illustrating this
is published in the Indian
Journal of Ophthalmology.