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On this series of lectures
on biology of the eye,
I will review
the blood-retinal barrier,
which will go along
with this structure, function,
and also its relevance
to retinal diseases.
0:17
Eye disclosures are next.
0:21
And then, after, we will go on
to the initial experiment
that has been done
with trypan blue in the brain.
And this was repeated by us
later on
in the retina and choroid.
And you can see
that trypan blue
penetrates in to the lungs
and colors the lungs
and other tissues of the body
like the heart,
but does not stain the brain
or stains with the retina
that you can see on the fourth,
down in the picture.
0:55
The next slide shows you
that the relationship between
what I will describe afterwards,
as the inner blood-retinal
barrier
and outer blood-retinal barrier
join the endothelial,
the relationship between retina
and the blood capillary
in the capillaries
of the retinal vessel
and the retinal vessels
and in the relationship
with retinal pigment epithelium.
And you will see
that it communicates
between these layers
and this extracellular fluid
within the retina.
1:28
We, at that time
in initial studies,
in first studies
were done in '66, '67,
we showed
there was an efflux outflow of,
by active transport
from organic anions
like fluorescein,
out of the vitreous
in to the retina,
involving
the retinal pigment epithelial
and the retinal vessels.
