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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosures
- Experiment with trypan blue
- Two major components for the blood-retinal barrier
- Blood-ocular barriers and main fluid movements
- Tight-junctions in retinal vessels
- Retinal vessels from a 9-year old rabbit
- Inner blood-retinal barrier
- Pathways for solute movements in the inner BRB
- Outer blood-retinal barrier
- Transport mechanisms
- The concept of cell polarity at the BRB
- Tight junction (TJ) assembly
- Proteins in tight junction assembly
- BRB regulates the microenvironment of the retina
- Major types of transport mechanisms
- Representative transport processes at inner BRB
- Other regulatory factors
- BRB and ocular immune privilege
- Clinical evaluation of the BRB
- Leakage - measurement of blood-retinal barrier
- Alteration of the BRB in retinal disease
- Macular edema and the BRB
- Diabetic macular edema
- Segmentation analysis cirrus OCT – SD OCT
- Layer by layer – analysis of retinal thickness
- Subclinical vs. clinical macular edema
- Diabetic retinopathy – alteration of the BRB
- Superficial and the deep retinal capillary nets
- 470408FJ OD – NVE
- OCT – leakage mapping in a healthy eye
- OCT identification of the alteration of the BRB (1)
- OCT identification of the alteration of the BRB (2)
- BRB and treatments of retinal diseases
- Acknowledgements
Topics Covered
- Two major components for the blood-retinal barrier
- Blood-ocular barriers and main fluid movements
- Tight-junctions in retinal vessels
- Inner blood-retinal barrier
- Outer blood-retinal barrier
- Transport mechanisms
- The concept of cell polarity at the BRB
- Major types of transport mechanisms
- Clinical evaluation of the BRB
- Alteration of the BRB in retinal disease
- Diabetic macular edema
- BRB and treatments of retinal diseases
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Cunha-Vaz, J. (2016, April 27). The blood-retinal barrier [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 14, 2024, from https://doi.org/10.69645/HGCX4115.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. José Cunha-Vaz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Biology of the Eye
Transcript
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0:00
On this series of lectures
on biology of the eye,
I will review
the blood-retinal barrier,
which will go along
with this structure, function,
and also its relevance
to retinal diseases.
0:17
Eye disclosures are next.
0:21
And then, after, we will go on
to the initial experiment
that has been done
with trypan blue in the brain.
And this was repeated by us
later on
in the retina and choroid.
And you can see
that trypan blue
penetrates in to the lungs
and colors the lungs
and other tissues of the body
like the heart,
but does not stain the brain
or stains with the retina
that you can see on the fourth,
down in the picture.
0:55
The next slide shows you
that the relationship between
what I will describe afterwards,
as the inner blood-retinal
barrier
and outer blood-retinal barrier
join the endothelial,
the relationship between retina
and the blood capillary
in the capillaries
of the retinal vessel
and the retinal vessels
and in the relationship
with retinal pigment epithelium.
And you will see
that it communicates
between these layers
and this extracellular fluid
within the retina.
1:28
We, at that time
in initial studies,
in first studies
were done in '66, '67,
we showed
there was an efflux outflow of,
by active transport
from organic anions
like fluorescein,
out of the vitreous
in to the retina,
involving
the retinal pigment epithelial
and the retinal vessels.