Heritability and its uses

Published on April 18, 2016   45 min

Other Talks in the Series: Statistical Genetics

My name is Doug Speed, and I'm a Researcher at University College London Genetics Institute. And today, I will be telling about Heritability and Its Uses. And hopefully, I'll convince you why this is the most exciting area in Quantitative Genetics.
So there are two parts in this talk. First, I'll tell you about traditional heritability analysis, and then, I'll talk to you a bit about SNP-based heritability analysis, which is a very recent area in the last five years, and hopefully, I will give you an idea of all the uses it has in trying to understand complex trades.
So first of all, here are few books and papers which I find very useful. The first one is Introduction to Quantitative Genetics, and this has more details on lots of the first part of this talk. I've a second too, Introductory Statistics with R and Elements of Statistical Learning are both available at the author's web pages to view online. And then here I have major papers in the field of SNP-based heritability analysis, and so it'll be useful for later.
It's a bit hard to tell in that previous slide, so I've just added a bit of noise so you can see the individual SNP genotypes. So here we see that adding in copies of the mutant allele increases phenotype on average. So for example, if an individual has one copy, so it's genotype AG, for example, then their effect is higher than if they have zero copies AA. And then, if they have two copies GG, their effect is the same amount higher still. And what we can observe is a linear trend, so each copy of the mutant allele increases for phenotypic effect by the same quantity.