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Printable Handouts
Navigable Slide Index
- Introduction
- Inflammatory bowel diseases
- Geographical prevalence of IBD
- Incidence and prevalence of IBD: before 1960
- Incidence and prevalence of IBD: 1960- 1979
- Incidence and prevalence of IBD: 1980-2008
- Age and sex distribution of IBD
- Pathogenesis of IBD
- Genetic influence
- Genetic susceptibility concordance in twins
- Environmental triggers
- Nonpathogenic injury
- Environmental risk factors for IBD
- Ulcerative colitis and Crohn’s disease
- Differential diagnosis of IBD and IBS
- DDs of infectious and ulcerative colitis
- Approach to DD of ulcerative vs. Crohn’s colitis
- p-ANCA and ASCA in IBD
- Varieties of colitis
- Characteristic features of ulcerative colitis
- Anatomic extent of ulcerative colitis
- Endoscopic spectrum of severity
- UC – intestinal manifestations
- Gross pathology of ulcerative colitis
- UC - intestinal complications
- “Collar button” ulcers
- Malignant stricture
- Risk of colorectal cancer
- Factors modifying risk of colitis-associated cancer
- Colonoscopic surveillance for dysplasia
- Extraintestinal manifestations - disease activity
- Systemic complications - peripheral arthritis
- Systemic complications - skin lesions
- Systemic complications - eye lesions
- Systemic complications - bille duct lesions
- Distinguishing features of Crohn’s disease
- CD - anatomic distribution
- CD - clinical patterns
- CD - clinical patterns - inflammation
- CD - clinical patterns - fistulization
- CD - clinical patterns - cobblestoing
- X-ray appearance of ileitis
- Transmural inflammation
- CD - perineal fistulae & abscess
- CD - perineal complications
- CD - post operative recurrence rate
- Goals of therapy
- Ulcerative colitis therapy
- Crohn's disease therapy
- Conventional drug therapies
- Sulfasalazine
- Aminosalicylates
- Systemic corticosteroids
- Topical corticosteroids
- Metabolism of azathioprine and 6-MMP
- 6-MP as maintenance therapy for UC
- 6-mercaptopurine in active Crohn’s disease
- Adverse effects of 6-MP/azathioprine
- Methotrexate as maintenance therapy for CD
- Metronidazole
- Revolution in treatment of IBD
- Infliximab in active Crohn’s disease
- Infliximab for fistulizing Crohn’s disease
- Adverse effects of Infliximab
- Vedolizumab mechanism of action
- Guidelines of pregnancy
- UC - Indications for surgery
- Indications for surgery in ulcerative colitis
- UC - ileal pouch - anal anastomosis
- Pouchitis - treament options
- CD - indications for surgery
- CD - post-operative prophylaxis
- Microscopic colitis
- Microscopic colitis - collagenous colitis
- Microscopic colitis - lymphocytic colitis
Topics Covered
- Inflammatory bowel disease etiology
- IBD epidemiology
- IBD diagnosis
- Ulcerative colitis
- Crohn’s disease
- IBD clinical manifestations
- IBD therapy
Links
Categories:
Therapeutic Areas:
Talk Citation
Nielsen, O.H. (2016, February 29). Inflammatory bowel disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/UQPC1293.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ole Haagen Nielsen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Immunology & Inflammation
Transcript
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0:00
My name is Ole Haagen Nielson,
I'm Professor of Medicine
at Herlev Hospital,
University of Copenhagen,
which is an East Danish Center
for Inflammatory Bowel Disease.
And I will talk about
those diseases in the following.
0:17
Inflammatory bowel diseases
or IBD consists
of ulcerative colitis
and Crohn's disease,
which are
the two most prevailed diseases,
together
with microscopic colitis,
which is also rather frequent
in elderly persons
and a number
of other more rare diseases.
0:41
So inflammatory bowel diseases
are more frequent
in some parts of the world
than in others
and this slide shows
that especially
in Western Europe
and in North America,
it's rather frequent.
0:56
The development
of ulcerative colitis
over the years, this slide shows
ulcerative colitis
prevalence before 1960.
1:09
And so this slide shows
between '60 and '79.
1:17
And this shows from '80 to 2008.
And you should know that it is
the same the diagnostic criteria
which has been used.
So it is being
more and more frequent
and it is the same figures
for Crohn's disease.
1:38
When we talk about
ulcerative colitis
and Crohn's disease,
then they are more or less
equal between the sexes.
And the age of onset
is the fertile age,
especially.
The 20s and the 30s,
most often the diseases appear.