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1. Introduction
2. Genetics of cancer
3. Oncogenes
4. Tumor suppressor genes
5. Breast cancer "family 0"
6. The two-hit hypothesis
7. How much breast and ovarian cancer is hereditary
8. Hereditary susceptibility causes to ovarian cancer
9. Hereditary susceptibility causes to breast cancer
10. BRCA1 and BRCA2 mutations
11. Lifetime cancer risk in mutation carriers
12. Epidemiology: BRCA1 and BRCA2
13. Founder effect
14. Selected examples of founder mutations
15. BRCA1 and BRCA2 mutations in Ashkenazi Jews
16. Varied penetrance
17. New York breast cancer study (NYBCS)
18. NYBCS family 96: "low incidence family"
19. Family 96: BRCA1 5382insC
20. Relatives with BRCA1\2 mutations: breast cancer
21. Relatives with BRCA1\2 mutations: ovarian cancer
22. Relatives with BRCA1\2 mutations: cancer onset
23. Factors affecting penetrance
24. Factors not significantly associated with age
25. New York breast cancer study conclusions
26. Mutation detection for BRCA1 and BRCA2
27. Inherited large rearrangements in BRCA1\BRCA2
28. Genomic regions of BRCA1 and BRCA2
29. Genetics of breast cancer "mystery families"
30. Inherited breast and ovarian cancer
31. PALB2 1592delT in Finnish breast cancer families
32. PALB2 1592delT: Finnish prostrate cancer family
33. Genes for inherited breast cancer
34. Breast cancer genes and genomic integrity
35. Biology of breast cancer genes
36. Identification of inherited cancer risk
37. Benefits
38. Risk assessment
39. Cancer risk reduction in women
40. Preventive removal of ovaries
41. Women with increased-risk family history

Topics Covered

• General cancer genetics
• Tumor suppressor and oncogenes
• Knudson's 'two hit' hypothesis
• Genetic predisposition to breast and ovarian cancer
• How much breast and ovarian cancer is inherited and the causes (genes responsible)
• Cancer risk in populations
• Factors that affect penetrance
• Mutation detection
• Risk reduction and prevention strategies

Links

Series:

• Human Population Genetics I

Categories:

• Cancer
• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on November 11, 2017

Financial Disclosures

• Dr. Piri Welcsh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.