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1. Introduction
2. What is diabetes mellitus?
3. Diabetes mellitus: model for genetic studies
4. Predicted increase in diabetes incidence
5. Classification of diabetes mellitus
6. Genetics of diabetes mellitus
7. Paradigms
8. Candidate genes
9. Identification of diabetes genes
10. Monogenic forms of diabetes
11. Human HNF-1alpha/MODY3 gene polymorphisms
12. MODY-related genes and clinical phenotype
13. MODY genes and pancreatic beta-cell function (1)
14. Polygenic forms of diabetes
15. HLA in type 1 diabetes
16. Diabetes genetics and complex diseases genetics
17. INS in type 1 diabetes
18. Linkage analysis results summary
19. Genes for type 2 diabetes
20. TCF7L2 in type 2 diabetes
21. Linkage mapping of type 2 diabetes
22. Genome-wide association studies (1)
23. Genome-wide association studies (2)
24. Loci implicated in GWA
25. MODY genes and pancreatic beta-cell function (2)
26. Mapping determinants of human gene expression
27. Allelic variation in human gene expression
28. Identifying diabetes susceptibility genes
29. Identifying the signature of natural selection
30. Ancestral susceptibility models
31. Pattern of signal shaped by LD
32. Gene expression across primate species
33. A virtual tsunami of data
34. An optimistic view on diabetes genetics

Topics Covered

• Diabetes mellitus: definition, classification and its use as a model for genetic studies of complex disorders
• Genetic forms of diabetes mellitus: monogenic and polygenic
• Identification of diabetes genes
• Monogenic forms of diabetes: human HNF-1-alpha/MODY3 gene
• Polygenic forms of diabetes
• HLA and ISN in type 1 diabetes
• Genes for type 2 diabetes and linkage mapping
• TCF7L2 in type 2 diabetes
• Genome wide association studies and gene loci implicated in these studies
• Allelic variation in human gene expression
• Ancestral susceptibility models

Links

Series:

• Human Population Genetics I

Categories:

• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Nancy Cox has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.