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1. Introduction
2. Human lifespan - a heritable trait?
3. Human lifespan - a phenotype of vital importance
4. Lecture outline
5. Changes in human lifespan during the 20th century
6. Female life expectancy in the 20th century
7. Mortality reductions since 1950
8. Record life-expectancy
9. Germany 1980-2000 (1)
10. Germany 1980-2000 (2)
11. Germany 1980-2000 (3)
12. Lifespan - a plastic trait
13. Large variation in lifespan within a birth cohort
14. Chance
15. Lifespan C. elegans
16. Lifespan - summary
17. Lifespan phenotypes
18. Genetic epidemiology of lifespan
19. Family aggregation
20. Family data
21. Twin studies
22. Twin lifespan
23. The individual level of twin studies (1)
24. The individual level of twin studies (2)
25. The individual level of twin studies (3)
26. Human co-twin lifespan
27. Twin design
28. Genetic influence on human lifespan and longevity
29. Danish twin cohorts
30. Swedish twin cohorts
31. Finnish twin cohorts
32. Number of twin pairs
33. Twin-twin plot
34. Relative recurrence risk
35. Lifespan of twin by lifespan of co-twin
36. Change in lifespan of twin by lifespan of co-twin
37. Conclusion
38. The genetic architecture of human longevity
39. Genetic study design in longevity research
40. What has been found so far?
41. The frequencies of ApoE alleles vary with age
42. Molecular pathways that lengthen lifespan
43. Other good candidates
44. Guidelines for future studies
45. Collaborators

Topics Covered

• Human lifespan as a heritable trait
• Lifespan phenotypes
• Genetic epidemiology of human lifespan
• The genetic architecture of human longevity
• Genetic study designs in longevity research

Links

Series:

• Human Population Genetics I

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Kaare Christensen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.