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0:00
Hello.
My name is Chris Griffiths.
I'm foundation professor
of dermatology
at the University
of Manchester.
And today I'm going to
discuss with you psoriasis.
0:12
I'm going to cover
the following topics
over the course
of the lecture.
The demographics
of the disease,
what we know about
the morphology,
the phenotypes,
introduce you to
the current concepts around
the immunology of psoriasis
and the current concepts about
the genetics of the condition.
Psoriasis is not a disease
that affects just the skin,
but there are a number
of important
co-morbid conditions.
I'll then discuss the current
management of psoriasis
and how translational research
has allowed us to make
significant advances,
not just in the
current management,
but also in the proposed
future management
of the condition.
And I'll close
with a brief discussion of
how stratified medicine
will probably change
the landscape management
of psoriasis.
1:02
The story starts
about 200 years ago.
Robert Willan was the founder
of British Dermatology.
But he's important in the
context of this lecture
because he was
the first person
to accurately describe psoriasis
in a book published in 1808.
And not only did he describe
morphology,
as you can see on this slide,
but also was the first person
to accurately separate
psoriasis from leprosy.
1:32
But Robert Willan
was also a man
who was ahead of his time.
So not only did he describe
the morphology
of these lesions in his book,
"On Cutaneous Diseases,"
but he also
described the patients
who he was seeing
in his clinic in London.
And this a quote
from the book,
and he describes
his patients as,
"having the characteristics
of the sanguineous,
combined with
other appearances
belonging to
melancholic temperament."
So he is describing his patients
as being depressed,
and I'll come back to that
important issue
later in the talk.
