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Printable Handouts
Navigable Slide Index
- Introduction
- Research overview
- Interface between biomaterials and cells
- How biomaterials affect cell behaviors?
- Biomaterials and cell behaviors
- The importance of scale
- Nano- to micron-scale
- Osteoblast functions: scale is important for cells
- Cell adhesion on surface: scale is important
- Fibronectin interactions with nano-scale surfaces
- Improving hard tissue regeneration
- Nanocomposites for bone regeneration
- Osteoblast adhesion on nanocomposites
- Nanocomposites: 3D printed structures
- Osteoblast infiltration into 3D nanocomposites
- hMSC adhesion and osteogenic differentiation
- hMSCs: ALP activity and calcium deposition
- HA nanoparticles: coating material
- Translational research: from bench-top to bedside
- Next-generation implants
- Nanophase hydroxyapatite coating on Mg alloys
- Nanocomposite coating: biodegradable Mg alloys
- From random to ordered surface features
- Surface patterns regulate cell adhesion
- Biomaterials used in current medical implants
- Need for surface patterning on titanium
- Increased BMSC adhesion on smaller pattern
- BMSCs preferential spreading and alignment (1)
- BMSCs preferential spreading and alignment (2)
- Degree of alignment of BMSCs
- Different morphologies of BMSCs
- Different morphologies of BMSCs: quantification
- Summary
- Acknowledgment (1)
- Acknowledgment (2)
Topics Covered
- Research overview and multidisciplinary collaborations
- Interface between biomaterials & cells: how biomaterials affect cell behaviors
- Importance of scale
- Improving hard tissue regeneration
- Nanocomposites for bone regeneration
- Next-generation implants
- From random to ordered-surface features
- Surface patterning on titanium: BMSCs as a model
Talk Citation
Liu, H. (2015, June 30). Hard tissue nanomedicine - significance of nanostructures [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/NRHP9281.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Huinan Liu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Nanomedicine
Transcript
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0:00
Today's topic is on Hard Tissue Nanomedicine
Significance of Nanostructures.
I'm Huinan Liu, from the
Department of Bioengineering,
at the University of
California at Riverside.
I am also a faculty member of
our Interdisciplinary Materials
Science and Engineering Program and
the Bourns College of Engineering.
I'm a participating faculty
member of The Stem Cell Center
and the Inland Empire
Stem Cell Consortium,
at the University of
California at Riverside.
If you're interested in learning
more about our research,
please visit our website
listed on this slide.
0:37
First I would like
to give you overview
of our research and
multi-disciplinary collaborations.
If you look at this slide,
we have this big red circle.
Biodegradable materials and
nanostructured interfaces, which
indicates our core research focus.
Around it you will
see the blue regions,
indicate our materials of interest,
starting from, for example,
biodegradable metals, ceramic
nanoparticles, nanocomposites
of biodegradable polymers
and ceramic nanoparticles,
as well as how we could design
and utilize nanostructured surfaces
and coating for controlling cellular
interactions at the interface
of medical device and implants.
We are interested in material design
synthesis characterization,
as well as implant design fabrication.
Towards the right region,
you will see focused areas
around the regenerative medicine.
In different application
areas for example,
bone cartilage ligament, neuro
tissue regeneration, cardiovasular
and neurovascular applications,
neurological devices,
mainly towards reducing
infections in urological devices.
So we are interested in developing
virtual cellular models to study
cellular responses to
different nanostructures
and different bio materials.
We are also interested
in how we could utilize
these unique properties of
materials and nanostructures,
for controlling the
delivery of different drugs
for therapeutic purposes.
So along the way, we've collaborated
with clinicians and surgeons,
medical device and
the implant industry,
as well as FDA developing
in-vivo models to evaluate
the bio materials and nanostructures
while their functionality
in functional animal models.
Down the road in future, we're also
interested in pre-clinical models
for potential clinical translation.