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Printable Handouts
Navigable Slide Index
- Introduction
- Definitions
- Nomenclature
- Polymorphism types
- Polymorphisms in human gene pool
- Discovery of microsaellite polymorphisms
- Evidence of polymorphisms in human CA repeats
- Genotyping microsatellite polymorphisms
- Complications of microsatellite analysis
- Non-integer alleles
- Strand slippage
- Instrumentational improvement in genotyping
- Microsatellite genotyping output and cost
- Three basic microsatellite repeats
- Alternative names
- Distribution of STRs in whole human genome
- Diallelic short insertion/deletion polymorphisms
- Abundances of mono- and dinucleotide repeats
- Abundances of tri- and tetranucleotide repeats
- Applications of microsatellites
- Linkage disequilibrium
- STRP pairs showing allelic association
- Geoancestry of subjects from Dominican Republic
- Autozygous detection segments of chromosome 6
- Microsatellite mutation
- Informativeness of (CA)n versus number of repeats
- Microsatellite mutation events
- Distribution - mutation rate vs. repeat length
- Delta values versus repeat length
- Polymorphisms in human gene pool
- Biological function of microsatellites (1)
- Trinucleotide repeat diseases
- Biological function of microsatellites (2)
- Evolution of microsatellites
- A-rich microsatellites from retroposon poly-A tails
- Allele frequency distribution - ACT1A01
- Allele frequency distribution - AFM002zf1
- Human minisatellites
- Canonical minisatellites
Topics Covered
- Microsatellites: nomenclature and definitions
- Discovery
- Typing methodology
- Abundance and types
- Applications
- Mutation
- Biological functions
- Evolution
- Minisatellites
Talk Citation
Weber, J. (2007, October 1). Human microsatellite and minisatellite DNA polymorphisms [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/HVNB6098.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. James Weber has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.