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Printable Handouts
Navigable Slide Index
- Introduction
- What is disease?
- Two types of disease
- Inheritance of monogenic and complex diseases
- Worldwide cancer incidence
- Important events in human evolution
- Biological factors that influence disease
- Environmental factors that influence disease
- Studying both biological and cultural influences
- Why is it unusual to study both ?
- Different types of data - DNA
- Different types of data - Environmental
- Biocultural analyses of human phenotypes
- Health disparities
- Research questions (1)
- Skin color and blood pressure
- Research questions (2)
- Research project (1)
- Research project (2)
- Specific questions
- Cultural consensus measure of color (1)
- Cultural consensus measure of color (2)
- Estimating genetic ancestry
- Social classification and genetic ancestry
- Genetic ancestry or color better predict BP?
- Does cultural data alter the association?
- Why do cultural data reveal genetic association?
- What is this interaction between color and SES?
- New study: discrimination, social stressors
- Current study - Cultural data
- Current study - Genetic data
- Questions
- Joint ancestry and association mapping for BP
- Unfair treatment and money strain
- SNPs, BP and different measures of UT/ED
- Different SNPs with different measures of UT/ED
- Possible gene:environment interactions
- ACE Alu genotype interaction with UT other
- Take-home messages (1)
- Take-home messages (2)
- Take-home messages (3)
Topics Covered
- Biological and cultural influences on disease
- Complex diseases: multiple genetic and environmental
- Genetic factors: candidate genes and genetic ancestry
- Environmental factors: toxins, and less studied factors such as race
- Case study: association of candidate genes, genetic ancestry, race and socioeconomic status with blood pressure in Puerto Rico
- Case study: association of candidate genes, genetic ancestry, novel measures of discrimination with blood pressure in African Americans
Talk Citation
Mulligan, C. (2024, September 18). Biological and cultural influences on disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/ZOIG7491.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Connie Mulligan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Human Population Genetics II
Transcript
Please wait while the transcript is being prepared...
0:00
Hello.
I'm Connie Mulligan.
I'm a professor in the
Department of Anthropology
and also Associate Director
of the Genetics Institute
at the University of Florida.
And in this lecture I'm going
to talk about biological
and cultural influences on disease.
I'm a Human Geneticist
and I'm trained in molecular and population genetics.
However, I've been in an
Anthropology Department
for the past 15 years.
And this is given me an appreciation
for the value of including
non-genetic data,
such as cultural data,
and in investigation of
human health and disease.
I work with cultural anthropologists
in our department in my research,
and I'll talk some about that
research in this lecture.
But first, I'll give some
background information
on different types of disease and
how they have different causative
and risk factors.
Then I'll talk about some of my
research that combines genetic,
biological, and
cultural data to provide
a comprehensive investigation
into specific diseases.
My research takes a
very broad perspective
in order to encompass
more of the full range
of factors that influence
particular types of disease.
In other words, diseases that have
biological and cultural influences.
These types of diseases are
called complex diseases.
I'm also interested in
racial health disparities,
because they're both biological
and cultural influences
on racial health disparities.
1:16
What is a disease?
If we're going to talk
about what causes diseases,
we have to be sure we understand
exactly what a disease is.
Wikipedia says, "A
disease is a particular
abnormal, pathological
condition that affects
part or all of an organism."
This definition makes it
sound black and white.
You either have a
disease or you don't.
In reality, the transition from
healthy state to disease state,
at least in some cases, can
be gradual or progress slowly.
So that it's not
always apparent exactly
when someone develops a disease.