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Increasing tumor targeting efficacy by nanomedicine

Published on May 18, 2015   17 min

Other Talks in the Series: Nanomedicine

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0:00
Hello. My name Dongwoo Khang, professor at the Department of Molecular Medicine in Gachon University, located in South Korea. In this slide, I will be very happy to share recent technology to enhance tumor target by using nanotechnology.
0:15
In this slide, I'll talk about three chapters to improve tumor target accuracy. First, is physiochemical factors regulating biodistribution, and second is mesenchymal stem cell assist in nanodrug delivery. And last, transportation to the cancer organelles will be discussed.
0:34
At the very famous presentation by Dr. Richard Feynman at APS meeting about 60 years ago, nanotechnology of applied physics and electronics. So unfortunately although the medicine is the most critical issues in human beings. The nanomedicine was recently introduced. This is why, in biochemical pharmaceutics, it still follows traditional approach or making drugs, and too much excessive drug with core side effect.
1:06
This slide is rationale for discussing low target efficacy of drug. For example, when the cancer patient receives chemotherapy only 2% of injected drugs will reach the tumor site. In other words, 98% of injected drugs will spread over the rest the entire body without targeted drug delivery. This is the main reason for inducing side effect. Currently, antibody targeted strategy, like EGFR, records about two times higher than the combinational drugs. So this antibody approach, does not enough to upgrade the quality of chemotherapy patient.

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Increasing tumor targeting efficacy by nanomedicine

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