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0:00
Hello. My name Dongwoo Khang,
professor at the Department
of Molecular Medicine in Gachon
University, located in South Korea.
In this slide, I will
be very happy to share
recent technology to enhance tumor
target by using nanotechnology.
0:15
In this slide, I'll talk
about three chapters
to improve tumor target accuracy.
First, is physiochemical factors
regulating biodistribution,
and second is mesenchymal stem
cell assist in nanodrug delivery.
And last, transportation
to the cancer organelles
will be discussed.
0:34
At the very famous presentation
by Dr. Richard Feynman at APS
meeting about 60 years
ago, nanotechnology of
applied physics and
electronics. So unfortunately
although the medicine is the most
critical issues in human beings.
The nanomedicine was
recently introduced.
This is why, in
biochemical pharmaceutics,
it still follows
traditional approach
or making drugs, and
too much excessive drug
with core side effect.
1:06
This slide is rationale
for discussing
low target efficacy of drug.
For example, when the cancer patient
receives chemotherapy only 2%
of injected drugs will
reach the tumor site.
In other words, 98% of injected
drugs will spread over the rest
the entire body without
targeted drug delivery.
This is the main reason
for inducing side effect.
Currently, antibody targeted
strategy, like EGFR,
records about two times higher
than the combinational drugs.
So this antibody approach, does
not enough to upgrade the quality
of chemotherapy patient.
