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Printable Handouts
Navigable Slide Index
- Introduction
- How do we describe genetic variation?
- Four major factors of evolution: mutation
- Natural selection and drift
- Migration
- Role of demography in the study of evolution
- Calculating selection rate
- Balancing selection
- Drift and population size
- Drift and migration
- Drift, once the Cinderella of evolution
- The aim of the Parma valley study
- Computing expected genetic variation due to drift
- Computer simulation of drift in 22 villages
- Results of the computer simulation
- Equilibrium of migration and drift
- Calculation of drift in larger populations
- Population density and drift in the Parma valley
- Genetic variation plotted against population density
- Simulations of expected effect of drift on variation
- Simulation conclusions
- How fast is fixation or extinction under drift ?
- Founders' effect
- Evolutionary history and present genetic variation
- Prediction of evolutionary history using drift
- Model for evolution reconstruction
- The first application of the model
- Genetic distances based on blood groups (1)
- Genetic distances based on blood groups (2)
- Tree of evolution
- Is drift the only evolutionary factor involved?
- Anthropometric vs. genetic world tree
- Major differences between the two trees
- Conclusions (Cavalli-Sforza and Edwards, 1964)
- Molecular evolution reinforces importance of drift
- Kimura's theorem on molecular evolution (1)
- Kimura's theorem on molecular evolution (2)
- Molecular evolution of proteins
- Rate of molecular evolution varies among proteins
- Trees with proteins, trees with DNA
- An example of philogeographic analysis (1)
- An example of philogeographic analysis (2)
- Microsatellites
- Using microsatellites to define populations
- A tree with 30 microsatellites (1)
- A tree with 30 microsatellites (2)
- Graphic presentation of evolution data by PCA
- Eigenvalues and eigenvectors
- Understanding PCA
- PCA of 21 European populations (1)
- PCA of 21 European populations (2)
- Same European populations analyzed by tree
Topics Covered
- Four major factors of evolution: mutation, natural selection, drift, migration
- Role of demography in the quantitative study of evolution
- Drift: the Parma Valley study
- Equilibrium of migration and drift
- Founders' effect
- Reconstructing evolutionary history of a population
- Evidence of the importance of drift from molecular evolution
- Molecular evolution of proteins
- Trees with proteins and trees with DNA
- Phylogeographic analysis
- Microsatellites
- Graphic presentation of evolution data by principal components analysis
Talk Citation
Cavalli-Sforza, L.L. (2007, October 1). History and geography of human genetic diversity I [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/YQGV7938.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Luigi Luca Cavalli-Sforza has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
History and geography of human genetic diversity I
Published on October 1, 2007
48 min