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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline & Part 1
- Expansion of farming in Europe
- Gradient – range expansion from South-East?
- Stepping stone model (1)
- Stepping stone model (2)
- Migration and principal components
- Genes mirror geography in today’s Europe
- Structure of Europeans - isolation by distance?
- Haplotype diversity of Europeans
- Axis of variation in Europe
- Outline: Part 2
- Ancient DNA and anatomically modern humans
- Handling contamination using postmortem damage
- Contamination estimate from mitochondria
- SNP overlap with reference data
- Procrustes of genetics and geography
- Neolithic individuals and Europeans in the 1000GP
- Power of time-serial data
- Temporal simulations
- Explicit models and formal tests
- Outline: Part 3 (Scandinavia)
- Neolithic hunter-gatherers (h-g) & farmers co-exist
- Two different cultures
- Two different cultures: pottery
- Two different cultures: burials
- Pilot study
- Pilot study: results
- Expanded set of samples and sequence depth
- Sample locations in Sweden
- Ancient and current-day Eurasian individuals
- Similarity to Neolithic farmers & hunter-gatherers
- Negative correlation “h-g” and “farmer” alleles
- The fraction of Neolithic farmer ancestry
- Three groups contribute to current day Europeans
- Non-symmetric admixture
- FST – genetic differentiation
- Outline: Part 3 (Iberia and eastern Europe)
- (Mainly) Neolithic individuals from Hungary
- El Portalon (Sierra de Atapuerca)
- Genes mirror subsistence in Neolithic Europe (1)
- Genes mirror subsistence in Neolithic Europe (2)
- Diversity within ancient groups
- Conclusions
- Two patterns – reconciled by Neolithic expansion
- Acknowledgements
- Acknowledgements - collaborators
Topics Covered
- Patterns of genetic variation in Europe and the Neolithic
- Ancient DNA and anatomically modern humans (Challenges & Potential)
- The Neolithic transition in Europe (Scandinavia, Iberia and Eastern Europe)
Talk Citation
Jakobsson, M. (2020, October 7). Ancient DNA and human evolutionary inference [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/UBGE5542.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Mattias Jakobsson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Human Population Genetics II
Transcript
Please wait while the transcript is being prepared...
0:00
Hi, welcome everyone.
I'm Mattias Jakobsson.
I'm Professor of Genetics
at Uppsala University,
and I will be talking
about ancient DNA in
the human evolutionary inference.
And I'm mainly going to be focusing
on anatomically modern humans,
and what we actually can learn by
looking into genetic information
from modern humans from the
last, say, 10,000-5,000 years.
0:24
So my outline is the following;
I'm going to start by talking about
some patterns of genetic variation
in Europe, and how they
can be interpreted in terms
of the neolithic transition
and the introduction
of farming into Europe.
And while I've done
that and only focused
on modern day genetic variation,
I'm going to switch gear a bit,
and in the second
part of this talk I'm
going to talk about
ancient DNA methods
for anatomically modern humans.
I will talk a little bit
about the challenges,
and I'll talk a little bit about
the potentials of using this data
of understanding our past.
After I've completed
the second part,
I'll come back to the
Neolithic transition
and what we can learn about the
past in Europe, as an example,
focus on Scandinavia
and Southern Europe,
and then I'll try to summarize
all this into a synthesis.
1:20
So it's well known from
the archaeological record
that farming practices started
some 10,000 to 12,000 years
in the Fertile Crescent
in the Middle East,
and that it spread relatively
rapidly over the next 5,000 years
to western, and southern,
and northern Europe.
And the ruling theory here has been
that the farming actually spread
as a movement of ideas,
or a movement of culture,
or even an idea that was actually
invented by the local hunter
gatherers living in the various
parts of Europe at the time.