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Printable Handouts
Navigable Slide Index
- Introduction
- Animal models in biomedical research
- Modeling psychiatric diseases
- Criteria for an optimal animal model
- Mouse models with targeted gene mutations
- Behavioral phenotyping
- Hypothesis testing
- Three-tiered strategy for behavioral phenotyping
- General health
- Neurological reflexes
- Motor skills
- Accuscan automated open field
- Rotarod
- Hanging wire
- Grip strength
- Sensory skills
- Acoustic startle and prepulse inhibition
- Olfactory habituation/dishabituation
- Anxiety-related conflict tests
- Elevated plus-maze
- Light vs. dark exploration
- Behavioral despair tests and antidepressants
- Porsolt forced swim test
- Tail suspension
- Nociception
- Hot plate analgesia
- Tail flick analgesia
- Learning and memory tests
- Morris water maze
- Contextual and cued fear conditioning
- Novel object recognition
- Novel object recognition - data
- Touchscreen operant learning
- Autism
- Causes of autism(s)
- Mouse models of autism spectrum disorder
- Testing genetic hypotheses about autism causes
- Mutant mouse models of autism
- Diagnostic symptom 1: social
- Core symptom #1: social interactions
- Three chambered social approach
- Reciprocal social interactions
- Communication
- Olfactory pheromones
- Ultrasonic vocalizations in social interactions
- Diagnostic symptom 2: insistence on sameness
- Core symptom #2: repetitive behaviors
- Mouse assays for stereotyped/repetitive behaviors
- Repetitive self-grooming
- Autism-relevant phenotypes: experimental design
- Key experimental design issues
- Control measures
- Example of unproblematic general health results
- What's wrong with my mouse?
- Current protocols in neuroscience
- Summary
Topics Covered
- Contribution of animal models to biomedical research
- Modeling psychiatric diseases
- Targeted gene mutations mouse models
- Behavioral phenotyping: a three-tiered strategy
- General health, neurological reflexes, sensory, motor abilities and specific tests
- Mouse models for autism
- Key experimental design issues
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Crawley, J.N. (2024, July 2). Behavioral phenotyping of mouse models of neuropsychiatric and neurodevelopmental disorders [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/QKJI7514.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jacqueline N. Crawley has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Behavioral phenotyping of mouse models of neuropsychiatric and neurodevelopmental disorders
Other Talks in the Series: Animal Models in Biomedical Research
Transcript
Please wait while the transcript is being prepared...
0:00
Hi.
I am Jacqueline Crawley
at the MIND Institute
at the University of California,
Davis in Sacramento in the US.
And we'll be talking to you today
about behavioral phenotyping
of mouse models of neuropsychiatric
and neurodevelopmental disorders,
a field that our Behavioral
Neuroscience Laboratory has
been working on for over 30 years.
0:26
The fundamental question
that you might ask
is, why would one bother using an
animal model in the first place?
How do animal models contribute
to biomedical research?
Basically, we're designing
research tools that will allow us
to discover the functions of
known and newly discovered genes,
or signaling proteins,
neurotransmitters, their receptors,
anatomical pathways,
epigenetic mechanisms,
specifically to understand
the causes of a human disease.
If we have a good
model, it then becomes
a pre-clinical tool that
tests potential treatments
for their efficacy and safety.
1:08
We understand completely,
particularly in terms
of psychiatric disorders, that we
can't anthropomorphize from a mouse
to a human, that
we're not pretending
that we work on an anxious,
depressed, schizophrenic, or
autistic mouse.
We never use those terms in our lab.
What we're doing is employing the
mouse behaviors that have features
that are similar to
the human symptoms,
or causes that are
similar to those that
are known to cause
the human disease,
or the same response
to a therapeutic drug.
And again, the goal is to
test hypotheses about causes
and to evaluate the potential
usefulness of treatments
of the human disorder.
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