AMPA-receptors and fast synaptic transmission in the brain

Published on January 19, 2015   36 min
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Hello, I'm Stuart Cull-Candy from University College London. And I'm going to be considering some of the cellular and molecular aspects of synaptic AMPA-type glutamate receptor that allow them to mediate false synaptic transmission in the brain. So I'll be considering how the functional properties of these receptors shape the transmission process.
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And I'm going to be covering five main topics indicated in this slide. I'll start by describing broadly, how AMPA-receptors mediate the fast component of excitatory transmission in the brain. Secondly, I'll address the question of how many functionally distinct types of AMPA-receptors are involved in transmission and the functional importance of their topology. Third, I'll consider how AMPA-receptor diversity shapes synaptic transmission and the implications of their differential distribution and plasticity. Fourth, I'll ask how AMPA-receptor structure affects its behavior and properties. And fifth, I'll ask what role do auxiliary AMPA-receptor proteins, such as stargazin, play in controlling AMPA-receptor properties and diversity.
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AMPA-receptors and fast synaptic transmission in the brain

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