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Printable Handouts
Navigable Slide Index
- Introduction
- Talk topics
- Question 1
- Excitatory central synapse
- Glutamate as a neurotransmitter - history
- Postsynaptic AMPA- and NMDA receptors (1)
- Postsynaptic AMPA- and NMDA receptors (2)
- Question 2
- Ionotropic glutamate receptor subunits
- AMPAR subunit topology
- Glutamate receptors & K+ channels homology
- AMPAR-subunits edited residues & splice variants
- Question 3
- Distribution and plasticity of AMPAR subunits
- Three types of change in AMPARs
- Implications on synaptic transmission
- Effect of editing on AMPAR subunits
- ‘Flip’ and ‘flop’ and AMPAR desensitisation
- Desensitisation of heteromeric AMPARs
- Main message
- Question 4
- How transmitter molecules open channels
- AMPAR gating mechanism
- Channel conductance & agonist binding sites
- Question 5
- Auxiliary transmembrane AMPAR subunit proteins
- Stargazin alters AMPAR functional properties
- Variety of auxiliary AMPAR regulatory proteins
- Acknowledgements and thanks
Topics Covered
- The fast component of excitatory synaptic transmission in the brain mediated by AMPARs
- Functionally distinct AMPAR subtypes are involved in transmission (importance of topology)
- How AMPAR diversity shapes transmission (implications of differential distribution and plasticity)
- How AMPAR structure affects its behaviour and properties
- Role of auxiliary AMPAR proteins (stargazin) in controlling AMPAR properties and diversity
Links
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Therapeutic Areas:
Talk Citation
Cull-Candy, S. (2015, January 19). AMPA-receptors and fast synaptic transmission in the brain [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/SNDD1416.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stuart Cull-Candy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello,
I'm Stuart Cull-Candy
from University College London.
And I'm going to be considering
some of the cellular and molecular
aspects of synaptic AMPA-type
glutamate receptor that allow them
to mediate false synaptic
transmission in the brain.
So I'll be considering how
the functional properties
of these receptors shape
the transmission process.
0:22
And I'm going to be
covering five main topics
indicated in this slide.
I'll start by describing broadly,
how AMPA-receptors mediate
the fast component of excitatory
transmission in the brain.
Secondly, I'll address the question
of how many functionally distinct
types of AMPA-receptors are
involved in transmission
and the functional
importance of their topology.
Third, I'll consider how
AMPA-receptor diversity shapes
synaptic transmission and the
implications of their differential
distribution and plasticity.
Fourth, I'll ask how
AMPA-receptor structure
affects its behavior and properties.
And fifth, I'll ask what role do
auxiliary AMPA-receptor proteins,
such as stargazin,
play in controlling
AMPA-receptor properties
and diversity.
1:12
So let's start by asking, how
do AMPA-receptors mediate
fast synaptic
transmission in the brain?
Well, as you know, in the
brain, neighboring neurons
are in very close proximity,
but they're not usually
in close enough physical
contact for the nerve impulse
to jump across the intervening
gap between the cells.
So to achieve this,
a majority of neurons
use a chemical transmitter that's
released from the presynaptic cell.