Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Cell differentiation, proliferation and death
3. Cell death programs in the nervous system
4. PCD regulates development of the nervous system
5. Similarities and differences in the PCD paradigm
6. NGF withdrawal
7. Conserved death mechanisms
8. Boxing cell death: different death programs?
9. Different death subroutines?
10. Intracellular ATP level
11. Common characteristics of cell death programs
12. Different executioners and cell death routines
13. Mechanisms of neuronal death after brain ischemia
14. Calcium deregulation in brain ischemia
15. Calcium homeostasis
16. Calcium deregulation in excitotoxic death
17. Calpains cleave NCX3 and affect calcium load
18. Monitoring calpain activation in neurons
19. Calpain isoform prevents lethal calcium overload
20. NCX3 siRNA generates excitotoxic triggers
21. NCX2 isoform prevents excitotoxicity
22. Spatial control of cell death
23. Death of cell bodies and axo-dendritic
24. Wallerian degeneration
25. Spatial control of neurodegeneration
26. BoNT/C as tool to inflict synaptic damage
27. BoNT/C causes neurodegeneration in neurons
28. BoNT/C effects
29. Distribution of mitochondrial dysfunction
30. Mitochondria retain integrity
31. Caspase-3 in cell soma and projections
32. Distribution of neuronal clearing by microglia
33. Exposure of phagocyte-recognition molecules (PS)
34. Spatial control of cell death in central neurons

Topics Covered

• Cell death programs in the nervous system
• PCD
• Similarities and differences in the classical PCD paradigm between worms and vertebrates
• Conserved death mechanisms
• Apoptosis, necrosis and autophagic cell death
• Other death subroutines
• The caspases
• Intracellular ATP level
• Common characteristics of cell death programmes in vertebrates
• Different executioners and cell death routines
• Brain ischemia
• Calpain activation
• Spatial control of cell death
• Spatial control of neurodegeneration
• BoNT/C
• Mitochondrial dysfunction
• Spatial control of cell death in central neurons

Links

Series:

• Apoptosis

Categories:

• Cell Biology
• Neuroscience

Therapeutic Areas:

• Immunology & Inflammation
• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 28, 2025

Financial Disclosures

• Prof. Pierluigi Nicotera has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.