Dynamic reciprocity and wound healing

Published on October 7, 2014   26 min

Other Talks in the Series: Wound Healing

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My name is Ira Herman. I am a Professor of Developmental Molecular and Chemical Biology at the School of Medicine, Tufts University in Boston, Massachusetts, where I direct the Center for Innovations in Wound Healing Research, and a graduate program in Cellular and Molecular Physiology. Today I'll be sharing some insights linked to dynamic reciprocity. And how this notion of a dynamic and reciprocal signaling network plays pivotal roles in regulating both the cellular responses to injury and control of wound healing. And why, in the context of non-healing wounds, this dynamic and reciprocal signaling between the cells of the epidermal compartment and the dermal compartments, why this dynamic reciprocity is disrupted and actually could contribute to, or be responsible for, the non-healing dynamics that are known.
So we'll begin by considering what might be a simple definition of what is dynamic reciprocity. Then, talk about how this paradigm could, and does, apply well to the notions of healing. And then talk about the extracellular matrix, and how this relationship between cells and their underlying, or surrounding extracellular matrix, contributes to the dynamics in the cellular responses that occur during reparative healing.
So on the second slide there is this is original definition, as we call it. Where did the term come from? Actually, it doesn't really derive from biological sciences, but it was actually recognized and re-coined in the context of biology by Mina Bissell and her colleagues, last century in the 1980s. And it was immediately recognized by us, and others, that dynamic reciprocity could be an important biological term to help to describe the regulatory role that the extracellular matrix plays in modulating cellular function. Regardless of whether we're talking about signals for growth, signals for differentiation, or the remodeling of tissues that take place during the development of the organism or adult life, and especially during disease, and in our case, injury and repair.