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Negative pressure wound therapy: mechanisms of action and clinical uses
Published on October 7, 2014 32 min
Other Talks in the Series: Wound Healing
Molecular and cellular regulation of wound healing; what goes wrong when wounds fail to heal or heal too much?
- Prof. Gregory Schultz
- University of Florida, USA
Understanding poor lymphatic function and how to improve it: revisiting old facts and examining new leads to help wounds heal
- Prof. Neil Piller
- Flinders University, South Australia, Australia
Hello, I'm Doctor Dennis Orgill, and today I'd like to talk about negative pressure wound therapy, mechanism of action, and clinical uses.
For financial disclosures, I've had passed research funding and have been a consultant and an expert witness for KCI.
Today we'll begin by discussing the history and technology transfer of negative pressure wound therapy devices, we'll review the biology of skin stretching, and we'll talk about the four primary mechanisms of negative pressure wound therapy, which include macrodeformation, microdeformation, fluid removal, and a moist wound environment. We'll then discuss secondary mechanisms which include, angiogenesis, inflammation, regulation of matrix metalloproteinases, and their effect on peripheral nerves. Finally, we'll go over some case examples including sternal wounds, open abdomens, groin wounds, and skin grafts following a brief discussion.
When clinicians started using negative pressure wound therapy devices, they had some amazing results. On the left you see a patient of ours who came into the hospital with necrotizing faciitis. She had peripheral vascular disease and diabetes, and this required a hip disarticulation. We placed the vac device on and changed it over 30 days. Normally we would have put a large flap on this, but she was too sick in the ICU. This could eventually be covered with a skin graft to close the wound. On the right, we commonly use a vac device to cover skin grafts, and this shows how this is applied to a lower leg wound.