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Alzheimer’s disease: current status of genetics research
Published on July 1, 2014 39 min
Other Talks in the Series: The Genetic Basis of Neurological Disorders
Neurodegenerative disease: the medical imperative for the developed world
- Prof. John Hardy
- Institute of Neurology, University College London, UK
My name is Rita Guerreiro and I'm at the Institute of Neurology in London. And in this lecture, I'm going to talk about Alzheimer's disease with a particular focus on the current status of genetics research in this disease. I will refer to several concepts, mainly genetic methods and technologies without describing them, because these have been the subject of a previous lecture in this series.
This talk is divided in two main parts. In the first part, I will give a brief overview of the central features of Alzheimer's disease and I will talk about the first genetic findings in this disease. In the second part, I will introduce the leading results from the application of recently developed genetic technologies to the study of dimentia, with a focus on the use of XM sequencing in Alzheimer's disease. I will end this lecture by summarizing all the main topics that were discussed.
Alzheimer's disease is a neurodegenerative disease and is the most common cause of dimentia in the elderly, accounting for 60% to 75% of these cases. The frequency of Alzheimer's disease doubles every five years, increasing from affecting 1% of individuals age 60 to 64 years to 35% to 45% of those over 85 years of age. The 2012 Alzheimer's Society dementia report estimated the total financial annual cost of dementia to the UK to be over a 23 billion pounds, with over 80,000 people living with this condition in this country. Worldwide, 25 million people are estimated to have dimentia. And by 2050, this figure is expected to rise to 14 million cases. And the costs associated with this disease will rise to extremely large numbers as the world population ages. Currently, there is no known cure for Alzheimer's disease.