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Printable Handouts
Navigable Slide Index
- Introduction
- First comprehensive study of melanoma cases
- Anatomy and architecture of human skin
- Epidermal melanocytes
- Melanocytes
- Factors essential for melanocytes development
- Clues from genetics
- Two classes of pigment mutants
- MITF is critical for melanocyte development
- What MITF does as a protein
- MITF gene locus: M-MITF promoter (1)
- MITF gene locus: M-MITF promoter (2)
- MSH induces MITF expression
- Posttranslational modifications on MITF
- The pathway underlying UV-induced pigmentation
- Rescuing melanin pathway downstream of MC1R
- PDE4D3: targeted by MITF
- Topical skin darkening by PDE inhibitors
- Human melanomagenesis
- MITF E318K in familial melanoma pedigrees
- Loss of SUMO-modification by MITF E318K
- Discovery of BRAF mutations in melanoma
- B-Raf mutations in Nevi
- BRAF V600E is sufficient to induce melanoma
- Oncogene discovery
- Oncogenic mutations
- Targeted therapy
- BRAF (V600E)
- BRAF signaling in normal cell
- Melanoma cells with BRAF mutation
- Normal cell with BRAF inhibitor
- B-RAF and MEK inhibition
- Combination therapy
- Conclusions
Topics Covered
- Melanocyte development
- key factors regulating lineage development
- relationships to pigmentation diseases
- MITF
- IV-induced pigmentation
- melanoma-genesis
- melanoma oncogene discovery
- BRAF-targeted therapy
- immunotherapy
- red pigment and melanoma-genesis.
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Fisher, D.E. (2014, May 4). Disorders of pigmentation: melanoma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/MDRW9125.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David E. Fisher has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
This is Dr. David Fisher from
the Department of Dermatology
at Massachusetts General Hospital.
I'm pleased to present
today's lecture, entitled
Disorders of Pigmentation
and Melanoma.
0:13
Probably the first
comprehensively presented
series of melanoma patients appeared
way back in 1857, as depicted
in this particular report by Dr.
William Norris, who was describing
a set of patients with a condition
associated with a hyper pigmented,
atypical, melanocytic disorder
that probably represented one
of the initial descriptions
of human melanoma.
0:40
This slide presents a
depiction in graphical form
of the anatomy and
architecture of human skin.
You will notice the
word epidermis describes
the most superficial
layers of the skin.
We will see in a
moment greater detail
of the structure of the epidermis.
But it is the epidermis which
is visible to the outside.
It's the epidermis
through which other organ
structures, such as
hairs, protrude.
And it is really the
epidermis that represents
the most crucial functional
barrier that protects the inside
of our bodies from the
outside environment.
Deep into the epidermis lies
the dermis and the hypodermis.
Within these structures reside
numerous other organelles
that have specialized function,
both in maintaining the skin itself,
and also in permitting communication
and protection to the organism
through their specific interactions.
The skin is frequently
described as the largest organ
in the human body, given
its cumulative surface area.
And it carries out numerous
highly differentiated
and specialized functions that
are vital for human health.