• Archived Lectures *These may not cover the latest advances in the field
• 38 min
  1. Segregation analysis

  • Prof. Chris Cannings
  • Dr. Dawn Teare
• 35 min
  2. Choosing the right study design in genetic epidemiology

  • Prof. Duncan Thomas
• 27 min
  3. Genome-wide scans

  • Prof. Michael Province
• 40 min
  4. The study of candidate genes in drug trials - sample size considerations

  • Prof. Robert Elston
• 48 min
  5. Graphical modelling of linkage disequilibrium

  • Prof. Alun Thomas
• 50 min
  6. Bayesian approaches for modelling complex metabolic pathways

  • Prof. Duncan Thomas
• 53 min
  7. Current methods for the analysis of genetic case-control data: a review

  • Prof. Duncan Thomas
• 44 min
  8. Detecting and correcting for population structure in genetic case-control studies

  • Dr. Jonathan Pritchard
• 57 min
  9. Statistical characterization of genetic association

  • Prof. Bruce Weir
• 34 min
  10. Haplotype-based mapping and pharmacogenetics

  • Prof. David Goldstein
• 50 min
  11. Genetic linkage analysis

  • Prof. Christopher Amos
• 30 min
  12. Use of DNA pooling in large-scale association studies

  • Prof. Pak Sham
• 29 min
  13. Searching for genetic association using (haplotype) tagging SNPs

  • Prof. David Clayton
• 27 min
  14. Heterogeneity: problems and solutions

  • Prof. Michael Province
• 37 min
  15. Introduction to population genetics 1: single locus

  • Prof. David Balding
  • Dr. Andrew Morris
• 57 min
  16. Haplotype phase inference

  • Prof. Peter Donnelly
• 38 min
  17. Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning

  • Prof. Newton Morton
  • Dr. Andrew Collins
• 58 min
  18. Introductory genetics for statisticians

  • Prof. Robert Elston
• 30 min
  19. Nature, nurture, neither?

  • Prof. Steve Jones
• 35 min
  20. Introduction to population genetics 2: linkage disequilibrium

  • Prof. David Balding
  • Dr. Andrew Morris
• 34 min
  21. Fine-scale mapping

  • Prof. David Balding
  • Dr. Andrew Morris

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Albert Einstein
3. Heterogeneous vs. homogeneous
4. Example: hypertension
5. Mixing apples and pears (1)
6. Mixing apples and pears (2)
7. Mixing apples and pears (3)
8. Types of heterogeneity (1)
9. Types of heterogeneity (2)
10. Types of heterogeneity (3)
11. Types of heterogeneity (4)
12. Modeling heterogeneity vs. detecting heterogeneity
13. Example: population stratification
14. Case study: family blood pressure program: FBPP
15. FBPP study designs
16. FBPP data characteristics
17. FBPP pooled data differences
18. Is AGT-6 an education gene? (1)
19. Is AGT-6 an education gene? (2)
20. Is AGT-6 an education gene? (3)
21. Is AGT-6 an education gene? (4)
22. Is AGT-6 an education gene? (5)
23. Is AGT-6 an education gene? (6)
24. Race is hidden stratification
25. Moral of the story
26. Detecting heterogeneity using TREE models
27. TREE notation (1)
28. TREE notation (2)
29. TREE building (1)
30. TREE building (2)
31. Classification TREEs (1)
32. Classification TREEs (2)
33. Classification TREEs (3)
34. Regression TREEs (1)
35. Regression TREEs (2)
36. Genotype-phenotype correlation in hypertension
37. Haseman-Elston linkage
38. TREE linkage idea...
39. Haseman-Elston TREE linkage (1)
40. Haseman-Elston TREE linkage (2)
41. Haseman-Elston TREE linkage (3)
42. Haseman-Elston TREE linkage (4)
43. Haseman-Elston TREE linkage (5)
44. Monte Carlo Evaluation
45. The heterogeneoty challenge
46. References

Topics Covered

• Heterogeneity: definitions and effects
• Phenotypic, genotypic, population and penetrance/expression heterogeneity
• Population stratification: case study
• Detecting heterogeneity: Tree models
• Classification vs. regression TREEs
• Application: Haseman-Elston TREE linkage

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Michael Province has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.