Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Albert Einstein
3. Heterogeneous vs. homogeneous
4. Example: hypertension
5. Mixing apples and pears (1)
6. Mixing apples and pears (2)
7. Mixing apples and pears (3)
8. Types of heterogeneity (1)
9. Types of heterogeneity (2)
10. Types of heterogeneity (3)
11. Types of heterogeneity (4)
12. Modeling heterogeneity vs. detecting heterogeneity
13. Example: population stratification
14. Case study: family blood pressure program: FBPP
15. FBPP study designs
16. FBPP data characteristics
17. FBPP pooled data differences
18. Is AGT-6 an education gene? (1)
19. Is AGT-6 an education gene? (2)
20. Is AGT-6 an education gene? (3)
21. Is AGT-6 an education gene? (4)
22. Is AGT-6 an education gene? (5)
23. Is AGT-6 an education gene? (6)
24. Race is hidden stratification
25. Moral of the story
26. Detecting heterogeneity using TREE models
27. TREE notation (1)
28. TREE notation (2)
29. TREE building (1)
30. TREE building (2)
31. Classification TREEs (1)
32. Classification TREEs (2)
33. Classification TREEs (3)
34. Regression TREEs (1)
35. Regression TREEs (2)
36. Genotype-phenotype correlation in hypertension
37. Haseman-Elston linkage
38. TREE linkage idea...
39. Haseman-Elston TREE linkage (1)
40. Haseman-Elston TREE linkage (2)
41. Haseman-Elston TREE linkage (3)
42. Haseman-Elston TREE linkage (4)
43. Haseman-Elston TREE linkage (5)
44. Monte Carlo Evaluation
45. The heterogeneoty challenge
46. References

Topics Covered

• Heterogeneity: definitions and effects
• Phenotypic, genotypic, population and penetrance/expression heterogeneity
• Population stratification: case study
• Detecting heterogeneity: Tree models
• Classification vs. regression TREEs
• Application: Haseman-Elston TREE linkage

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Michael Province has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.