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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosures
- Overview
- Adipose tissue
- Adipose tissue as a bioresource
- Cell isolation from adipose tissue
- Terminology and definitions (1)
- Terminology and definitions (2)
- SVF cell yield
- Characterization of cell surface markers
- Cell surface markers of adipose derived cells
- A joint publication by the IFATs and ISCT
- Guidelines for characterization
- Characterization by function/behavior
- Developmental plasticity of adipose cells
- Summary of adipose cells differentiation
- Paracrine effects
- Immuno-modulatory/anti-inflammatory perspective
- Microvascular remodeling after hASC injection
- Where do ASCs reside?
- Are pericytes and MSCs the same cell?
- Unresolved issues, questions and controversy
- Definition of stem cell
- SVF/ASC isolation variables
- Reductionist approach
- The reductionist research conundrum
- Systems approach
- The "stem cell" concept
- Changing the way we think about stem cells
- Storm clouds and stem cells (1)
- Storm clouds and stem cells (2)
- The niche
- Methods
- Differences in genotype and cell surface marker
- 3-D spheroid system
- In vivo adipogenesis with 3D culture
- Histology of implants
- 3D spheroid culture and osteogenic induction
- In vivo osteogenesis of human ASCS
- Future of study of adipose derived cells
- Translation
- The adipose therapeutic spectrum
- Translational strategies
- Current clinical work
- Commercialization
- Enabling translation of adipose-derived therapies
- Point-of-care SVF cell isolation
- Conclusions (1)
- Conclusions (2)
- Conclusions (3)
- Acknowledgements
Topics Covered
- Adipose Tissue Histology
- Adipose Tissue as a BioResource
- Adipose-derived cells: Characterization
- Cell Isolation Variables
- In Vivo Cell Location
- Unresolved Issues, Questions and Controversy
- How Should We Study Stem Cells?
- Self-assembling, 3-dimensional Spheres in Suspension Culture: An In Vitro Niche Model
- Advantages of 3-D Spheroid ASC Culture
- Translation of Adipose-derived Cell Therapies
- Commercialization
Links
Series:
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Therapeutic Areas:
Talk Citation
Katz, A.J. (2014, March 5). Stem cells from adipose tissue [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 10, 2024, from https://doi.org/10.69645/RKOA7141.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Adam J. Katz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Cardiovascular & Metabolic
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, this is Adam Katz.
And the title of my presentation is
"Stem Cells from Adipose Tissue."
I am an associate
professor in the division
of plastic surgery at the
University of Florida.
0:14
As part of full disclosure, I would
like to mention that I am a named
inventor on issued and or
pending patents related
to the adipose field, including
adipose-derived cells and matrix.
And I have in the past received
royalties related to this IP.
I also serve on the
board of directors
or have been a founder
on at least two companies
that operate in this field.
0:40
As a brief overview
for my presentation,
I will be giving a brief background
on the adipose-derived cell,
as well as some of the
past and current science
related to these cells.
We'll also discuss briefly some of
the regulatory issues surrounding
the translation of
adipose-derived cells
and then the translation and
commercialization of these cells
specifically.
1:07
To begin, let's discuss adipose
tissue, which is a tissue many
of us are well aware
of and have learned
about in medical school or
other stages of training.
Many of us were taught that
the function of adipose tissue
was simply for storing
energy and providing
padding to important structures.
There are two main physiological
subcompartments of adipose tissue.
One is the parenchyma, which is
the functional part of the tissue.
In this case the adipocyte,
which stores energy.
And surrounding this is the stroma,
or the connective or supportive
structural framework of a tissue.
In this case, lots of fibroblasts
and endothelial vascular
related cells.
We now know that adipose
tissue in extremely
complex and dynamic endocrine organ.
And from our standpoint, for
the purpose of this talk,
we'll be talking about the
regenerative potential of cells
and factors that are
derived from this tissue.