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Navigable Slide Index

1. Introduction
2. Lecture plan
3. Antipsychotic drug treatment
4. Major side effects of the treatment of schizophrenia
5. Antipsychotic drug treatment: newer drugs
6. Antipsychotic drug-induced weight gain
7. Diabetes following antipsychotic treatment
8. Antipsychotic drug effects on weight gain
9. Weight gain studies in drug naive populations
10. Antipsychotic drug-induced weight gain: questions
11. Pharmacogenetic studies in schizophrenia
12. Receptor mechanisms of antipsychotic weight gain
13. 5-HT2C receptors and weight gain
14. 5-HT2C receptors, genes and weight gain
15. Pharmacogenetics of antipsychotic weight gain
16. Association study of 5HT2C receptor gene: Chinese
17. Expression of the Chinese study in a different way
18. Association study of 5HT2C receptor gene: Spanish
19. Mechanisms of the promoter polymorphism (1)
20. Mechanisms of the promoter polymorphism (2)
21. Olanzapine-induced weight gain
22. Functional mechanisms
23. Consequences of antipsychotic treatment
24. Leptin
25. Leptin, fat and food intake
26. Leptin promoter polymorphism and weight gain
27. Leptin association study
28. Blood leptin and 5-HT2C genotype
29. Genetic testing for drug-induced weight gain?
30. Metabolic consequences - future challenges

Topics Covered

• Antipsychotic drugs: limitations and side effects
• Drug-induced weight gain
• Severity and consequences
• Receptor mechanisms
• Role of 5-HT2C receptor
• Pharmacogenetics of antipsychotic weight gain: 5-HT2C promoter polymorphism
• Functional mechanism of polymorphism
• Role of leptin and leptin-promoter polymorphism
• Role of genetic testing
• Future directions

Links

Series:

• Psychopharmacogenetics

Categories:

• Genetics & Epigenetics
• Metabolism & Nutrition
• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Reynolds, G. (2007, October 1). Genetic determinants of antipsychotic-induced weight gain [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/JVNV2270.
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Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Gavin Reynolds has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.