• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Classification of hepatic encephalopathy (HE)
3. Acute liver failure (ALF)
4. Neuropathology of ALF (1)
5. Neuropathology of ALF (2)
6. Microglial activation and neuroinflammation in ALF
7. BBB breakdown in ALF- if infection\sepsis present
8. Pathogenesis of HE in ALF - key role of ammonia
9. Ammonia produced in the gut, removed by the liver
10. Arterial ammonia predicts brain herniation in ALF
11. Arterial NH3: risk factor of intracranial hypertension
12. NH3 removal by brain: a neuroglial responsibility
13. Ammonia removal by brain
14. Selective gene expression alterations in ALF
15. Glial fibrillary acidic protein (GFAP)
16. Loss of GFAP mRNA in brain in ALF
17. GFAP levels & brain edema - negative correlation
18. Glutamate transporter EAAT-2
19. Glutamate transporters in forebrain
20. Decreased EAAT-2 mRNA/protein in brain in ALF
21. Consequence of loss of EAAT-2 expression
22. Extracellular brain glutamate & neurological status
23. Systemic inflammation in ALF
24. Neuroinflammation in ALF
25. Microglial activation and neuroinflammation in ALF
26. Brain cytokines in ALF
27. Brain cytokine gene expression in ALF: in rat
28. Brain cytokine gene expression in ALF: in mouse
29. Therapeutic implications
30. Do treatments act on neuroglial mechanisms?
31. Mild hypothermia limits microglial activation (ALF)
32. Mild hypothermia reduces brain cytokines (ALF)
33. Mild hypothermia reduces brain cytokine levels
34. NAC prevents neuroinflammation in ALF
35. Minocycline
36. Brain edema in ALF (minocyclin-protective effect)
37. Minocyclin and brain pro-inflammatory cytokines
38. Minocyclin and brain cytokine gene expression
39. Take home messages (1)
40. Take home messages (2)
41. Acknowledgements

Topics Covered

• Classification of hepatic encephalopathy
• Acute liver failure
• Neuropathology of Acute liver failure
• Pathogenesis of hepatic encephalopathy in Acute liver failure: key role of ammonia
• Arterial NH3: risk factor of intracranial hypertension
• Selective gene expression alterations in Acute liver failure
• Glial fibrillary acidic protein (GFAP)
• Glutamate transporter EAAT-2
• Extracellular brain glutamate and neurological status
• Systemic inflammation in Acute liver failure
• Brain cytokines in Acute liver failure
• Therapeutic implications

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on November 28, 2013

Financial Disclosures

• Prof. Roger F. Butterworth, Speaker’s Bureau: Merz Pharmaceuticals, Frankfurt, Germany.