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1. Introduction
2. Drug resistance mechanisms
3. Chloroquine-resistance in falciparum malaria
4. Chloroquine-resistance caused raised fatality
5. Resistance mechanisms
6. PfCRT (coded on chromosome 7)
7. PfCRT based on structure of E. coli 1PW5
8. The ancestor of PfCRT may be a thiol carrier CLT
9. Activity of D-AQ in CQ-R
10. AQ selected the SVMNT CQ-resistance variant
11. Can CQ become useful once more?
12. Resistance to artemisinin
13. Mutations in Pgh-1
14. PgH-1
15. Modeled PgH-1 transporter
16. Mouse PgH-1 transporter model
17. Mutated protein pumps more HF into the DV
18. Resistance mechanisms summary
19. Rationale for ACT
20. UBP-1 changes associated with drug-resistance
21. Piperaquine and dihydroartemisinin combination
22. Life cycle stage as drug target - summary (1)
23. Life cycle stage as drug target - summary (2)
24. Controlling the spread of resistance
25. Approach to urgent treatment for severe malaria
26. Intermittent preventive treatment: IPT

Topics Covered

• Drug resistance mechanisms
• Chloroquine-resistance in falciparum malaria
• PfCRT protein -Resistance to artemisinin
• PgH-1
• Rationale for Artemisinin combination therapy
• Controlling the spread of resistance
• Approach to urgent treatment for severe malaria
• Intermittent preventive treatment

Links

Series:

• Antibiotic Resistance

Categories:

• Clinical Practice
• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Warhurst, D. (2013, November 6). Advances in mode of action of antimalarials and resistance mechanisms 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/KDTO3619.
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Publication History

• Published on November 6, 2013

Financial Disclosures

• Prof. David Warhurst has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.