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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. The far-sighted macrophage
3. The near-sighted macrophage
4. A far-sighted receptor mechanism
5. A near-sighted receptor mechanism
6. An inconvenient observation
7. Beta-glucan structure
8. Dectin-1 versus beta-glucan structures
9. Binding of beta-glucan polymers and dectin-1 (1)
10. Binding of beta-glucan polymers and dectin-1 (2)
11. Binding of beta-glucan polymers and dectin-1 (3)
12. Exposing macrophage to beta-glucans
13. Soluble beta-glucans bind to dectin-1
14. Soluble glucans do not work
15. Soluble versus particulate beta-glucans
16. Immobilized glucans trigger dectin-1 signaling
17. Immunological synapse (1)
18. Immunological synapse (2)
19. CD45 and CD148
20. CD45 structure and function (1)
21. CD45 structure and function (2)
22. Do CD45 and CD148 regulate dectin-1 signaling?
23. Dectin-1 and CD45 during phagocytosis
24. Dectin-1 phagocytic synapse (1)
25. Dectin-1 phagocytic synapse (2)
26. Dectin-1 phagocytic synapse (3)
27. Dectin-1 phagocytic synapse: A. fumigatus
28. Dectin-1 signaling model
29. Dectin-1 signaling model: soluble glucans
30. Dectin-1 signaling model: immobilized glucans
31. Cells on glucan-coated plastic vs. control
32. Testing the dectin-1 signaling model
33. CD45 co-immobilization
34. Summary
35. On the term “phagocytic synapse”
36. Do other receptors require phagocytic synapse?
37. Further reading

Topics Covered

• The Phagocytic Synapse
• The ability of Phagocytes to discriminate between particulate ligands and soluble ligands
• The Dectin-1 "phagocytic synapse" as a model mechanism for how a surface receptor can distinguish between a particle and a soluble ligand

Links

Series:

• Cells of the Innate Immune System

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on November 27, 2013

Financial Disclosures

• Prof. David Underhill has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.