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1. Introduction
2. The hypothalamo-neurohypophysial system
3. Anatomical remodeling
4. Unstimulated
5. Stimulated
6. Consequences of the anatomical remodeling
7. Glutamatergic synapse (1)
8. Glutamatergic synapse (2)
9. Activation of the Glutamatergic synapse (1)
10. Activation of the Glutamatergic synapse (2)
11. Astrocytes control glutamate clearance
12. Heterosynaptic transmission
13. Anatomical remodeling causes increase in Glu
14. Glutamate spillover and remodeling of the SON
15. Diffusion: tortuosity and volume
16. Heterosynaptic modulation: GABAergic terminal
17. Heterosynaptic modulation due to Glu spillover
18. Two-stimulations paradigm
19. mGluRs and heterosynaptic depression of IPSCs
20. Activation of GluR on neighboring synapses
21. Retraction of the astrocytic process
22. Heterosynaptic depression & SON of lactating rats
23. Effects of limiting diffusion in extracellular space
24. NMDA receptors
25. NMDA receptor: model
26. Serine racemase in the SON
27. D-serine in the SON
28. DAAO degrades D-serine
29. AMPA and NMDA peak currents
30. D-serine is the endogenous ligand of NMDAR
31. NMDAR-mediated EPSCs in lactating rats
32. D-serine rescues NMDAR activity in lactating rats
33. D-serine levels in the cleft reduced in lactating rats
34. Long-term synaptic plasticity (1)
35. Ca2+ signaling requirement for LTD
36. Long-term synaptic plasticity (2)
37. Conclusions
38. Acknowledgments

Topics Covered

• Anatomical remodelling of the hypothalamo-neurohypophysial system during specific physiological conditions
• Charactersiation of this remodelling by reduction in the astrocytic coverage of manocellular neurons and their synapses
• Electrophysiological approaches show changes in the glial environment of neurons and synapses can dramatically alter synaptic functions
• The hypothalamo-neurohypophysial system as an experimental model to study the contribution of astrocytes to synaptic transmission and plasticity

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on November 5, 2013

Financial Disclosures

• Dr. Stéphane H.R. Oliet has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.