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1. Introduction
2. Myc - regulation and function
3. Myc gene rearrangements in cancer
4. Organization of Myc family proteins
5. Myc transcription complexes
6. Control of Myc levels
7. Mxd family of transcriptional repressors
8. Mxd1 SID domain
9. Myc and Mxd - functional antagonists
10. Myc-Max to Mxd1-Max switch during differentiation
11. Myc and Mad regulate histones acetylation state
12. An overview of the Myc-Max network
13. The drosophila Max network
14. Myc expression correlates with cell size
15. Increased dMyc expression produces larger cells
16. dMyc increases growth rate of cells
17. dMnt inhibits cell growth, attenuates proliferation
18. c-Myc expression and an increase in B cell size
19. Cell growth and cell proliferation
20. Drosophila and mammalian cells
21. Myc-Max proposed transcriptional cascade (1)
22. Myc-Max proposed transcriptional cascade (2)
23. dMyc, dMax, dMnt binding to genomic loci
24. Widespread binding to promoters containing E-box
25. Myc-Max binding effects and target genes
26. Functional classes of Myc-regulated genes
27. Myc affects cell growth via RNA POL I, II and III
28. Myc - roles and regulation in cellular metabolism
29. A new suggested extended network for Myc action
30. Myc transcriptional network overview
31. Non-transcriptional activities of Myc
32. Some open questions concerning Myc
33. Slide citations
34. Selected reviews and references
35. Acknowledgements

Topics Covered

• Myc plays a broad role in cellular functions
• Deregulation of Myc is associated with many cancers
• Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications
• Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism
• Myc also has functions unrelated to transcription

Links

Series:

• The Cell Division Cycle
• Epigenetics, Chromatin, Transcription and Cancer

Categories:

• Biochemistry
• Cancer
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on October 7, 2013

Financial Disclosures

• Prof. Robert N. Eisenman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.