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Printable Handouts
Navigable Slide Index
- Introduction
- Myc - regulation and function
- Myc gene rearrangements in cancer
- Organization of Myc family proteins
- Myc transcription complexes
- Control of Myc levels
- Mxd family of transcriptional repressors
- Mxd1 SID domain
- Myc and Mxd - functional antagonists
- Myc-Max to Mxd1-Max switch during differentiation
- Myc and Mad regulate histones acetylation state
- An overview of the Myc-Max network
- The drosophila Max network
- Myc expression correlates with cell size
- Increased dMyc expression produces larger cells
- dMyc increases growth rate of cells
- dMnt inhibits cell growth, attenuates proliferation
- c-Myc expression and an increase in B cell size
- Cell growth and cell proliferation
- Drosophila and mammalian cells
- Myc-Max proposed transcriptional cascade (1)
- Myc-Max proposed transcriptional cascade (2)
- dMyc, dMax, dMnt binding to genomic loci
- Widespread binding to promoters containing E-box
- Myc-Max binding effects and target genes
- Functional classes of Myc-regulated genes
- Myc affects cell growth via RNA POL I, II and III
- Myc - roles and regulation in cellular metabolism
- A new suggested extended network for Myc action
- Myc transcriptional network overview
- Non-transcriptional activities of Myc
- Some open questions concerning Myc
- Slide citations
- Selected reviews and references
- Acknowledgements
Topics Covered
- Myc plays a broad role in cellular functions
- Deregulation of Myc is associated with many cancers
- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications
- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism
- Myc also has functions unrelated to transcription
Links
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Talk Citation
Eisenman, R.N. (2013, October 7). The Myc transcription factor network [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 23, 2021, from https://hstalks.com/bs/2654/.Publication History
Financial Disclosures
- Prof. Robert N. Eisenman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The Myc transcription factor network
Published on October 7, 2013
47 min