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1. Introduction
2. Lecture overview
3. Dendritic cells in innate and adaptive immunity
4. Viral defense by mucosal dendritic cells
5. Inhibitors of DC-SIGN
6. The C-type lectin DC-SIGN
7. Common classes of mammalian glycans
8. Glycosylation occurs in the ER and the Golgi
9. DC-SIGN receptor for HIV1 and HCV on DC
10. Does DC-SIGN present to T cells?
11. HIV1 transmission to T cells by DCs
12. HIV1 transmission by DC-SIGN
13. DC-SIGN and HIV1 infection of T cells
14. Langerhans cells in HIV transmission
15. Langerhans cells
16. DC-SIGN as a pathogen receptor
17. Gp120 binding: carbohydrate fingerprint
18. Langerin protects HIV1 transmission by LCs
19. LC protects us against infection with HIV1
20. Bacteria recognition by human immune system
21. Pathogen-associated molecular patterns
22. Toll-like receptors
23. TLRs and C-type lectins
24. Antigen presentation by C-type lectins
25. Glycosylation
26. Glycan specificity of the C-type lectins
27. DC-SIGN binding pathogens
28. Orchestrating adaptive immune response
29. Helicobacter pylori
30. Phase variation of Helicobacter pylori LPS
31. DC-SIGN-mediated skewing of CD4 response
32. Mycobacterium tuberculosis
33. M. tuberculosis cell wall
34. DC-SIGN binds mycobacterial ManLAM
35. DC-SIGN enhances IL-10 responses
36. Targeting DC-SIGN to modulate immune response
37. C-type lectins (DC-SIGN) in bacterial infections
38. Cross-talk between pathogen receptors
39. C-type lectin function
40. Expression and binding of Lewis antigens
41. DCs interact with neutrophils through DC-SIGN
42. DC-SIGN binds 160 kD ligands on neutrophils
43. CEACAM1 binds DC-SIGN through Lewis
44. Mac1 and CEACAM1 on other cells
45. PMNs modulate DC-induced immune responses
46. PMN and DC - innate to adaptive responses
47. Glycan changes associated with cancer
48. DC-SIGN binds cancer-associated cell lines
49. CEA and CEACAM1 in colon carcinoma
50. Immature DCs bind CEA from tumor colon
51. CEA and CEACAM1 from colon carcinoma
52. C-type lectin function (2)
53. Acknowledgements

Topics Covered

• Function of Carbohydrate Recognition by C-type Lectins on Dendritic Cells in “Host Defense” and “Immune Homeostasis"
• Dendritic cells in innate and adaptive immunity
• Viral defense by mucosal dendritic cells
• Inhibitors of DC-SIGN block virus binding and cellular function
• The C-type lectin DC-SIGN
• Common classes of mammalian glycans
• DC-SIGN receptor for HIV-1 and Hepatitis C virus on DC
• Langerhans cells
• LC protects us against infection with HIV-1
• How are bacteria recognized by the human immune system?
• Pathogen-associated molecular patterns
• Toll-like receptors
• TLRs and C-type lectins
• Antigen presentation by C-type lectins
• Glycan specificity of the C-type lectins
• Orchestrating adaptive immune responses by pathogen recognition
• Helicobacter pylori
• Mycobacterium tuberculosis
• DC-SIGN enhances TLR-induced IL-10 responses
• Pathogens target DC-SIGN to modulate immune responses
• C-type lectins (DC-SIGN) in bacterial infections
• C-type lectin function
• DCs interact with neutrophils through DC-SIGN
• Glycan changes associated with cancer

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Van Kooyk, Y. (2013, September 23). Function of carbohydrate recognition by C-type lectins on dendritic cells in “host defence” and “immune homeostasis” [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 24, 2023, from https://hstalks.com/bs/2648/.
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Publication History

• Published on September 23, 2013

Financial Disclosures

• Dr. Yvette Van Kooyk has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.