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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- The ageing process
- Molecular damage
- Ageing and protein alterations
- Protein homeostasis mechanisms
- Enzymatic protein repair systems
- The proteasome
- Autophagy
- Other protein degradation systems
- Protein homeostasis and ageing
- Failure of protein homeostasis systems
- A reciprocal relationship
- Is protein synthesis a determinant of ageing?
- The model organism Caenorhabditis elegans
- C. elegans life cycle
- C. elegans anatomy and development
- Determinants of C. elegans ageing
- C. elegans lifespan plasticity
- Working hypothesis
- Control of protein synthesis
- eIF4E is a key regulator
- Five eIF4E isoforms in C. elegans
- Unexpected results
- Paradoxically, knockout of ife-2 extends lifespan
- Why specifically ife-2?
- Lifespan extension by IFE-2 depletion
- IFE-2 deficiency and insulin/IGF-1 pathway
- IFE-2 deficiency and dietary restriction
- Interim conclusion
- Phenotypic analysis of ife-2 mutants
- Hypothetical scenarios
- Revised working hypothesis
- IFE-2 deficiency reduces protein synthesis
- IFE-2 deficiency and oxidative stress
- mRNA translation and ageing
- Disposable soma theory
- Energy investment and ageing
- Ageing signaling pathways & protein synthesis
- Summary of the talk
- Credits
Topics Covered
- Ageing and senescent decline
- Protein modifications during ageing
- Main cellular protein homeostasis mechanisms
- Effects of ageing on protein homeostasis
- Regulation of protein synthesis
- Linking protein synthesis and ageing
Talk Citation
Tavernarakis, N. (2013, September 22). Protein homeostasis during ageing: C. elegans as a model organism [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 1, 2024, from https://doi.org/10.69645/MTTB7281.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Nektarios Tavernarakis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Cell Biology
Transcript
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0:00
Hello and welcome to this presentation on protein homeostasis during ageing.
My name is Nektarios Tavernarakis.
I'm a Professor at the University of Crete Medical School,
and a Research Director at the Foundation for Research & Technology in Heraklion, Crete, Greece.
In my talk, I aim to discuss the link between protein homeostasis in ageing at two levels.
First, what is the impact of ageing and senescent decline on protein homeostasis?
Secondly, how manipulations of protein homeostasis may influence organism and lifespan.
0:35
I will begin by introducing and defining
the phenomenon of ageing in relation to biological systems.
I will then focus on how the process of ageing
and senescent decline impacts proteins in the cell.
In other words, what deleterious alterations proteins suffer during ageing.
Third, I will give you an overview of
the cellular systems that are in place to maintain protein homeostasis.
In the fourth part of the talk,
I will discuss how these systems are influenced by ageing,
and what the consequences are on protein function and homeostasis.
Finally, I will present some of our own work that directly
implicates protein synthesis in the regulation of organismal lifespan.
1:17
Ageing is driven by inexorable and random incidence of damage to cellular constituents.
This continues white noise of random molecular damage
forms the bedrock for the advent of ageing.
In turn, molecular damage leads to accumulation of
cellular defects that gradually, and in time,
precipitate a decline in the function of cells,
organs and tissues, which can be manifested as
age-related frailty, disability and disease.