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1. Introduction
2. Outline
3. The global immune response of the lungs
4. Dendritic cells (DCs)
5. Localisation of DCs in epithelium
6. DCs probe the mucosa for incoming antigen
7. Activating DCs (1)
8. Activating DCs (2)
9. The dynamic behaviour of DCs in the airways
10. Airway DCs capture inhaled FITC-labelled OVA
11. What’s controlling dendritic cell traffic in the lung?
12. Controlling responsiveness to the node T cell area
13. Immunological synapse formation in the T cell area
14. Peptide presentation by MHC class II molecules
15. Cascade of costimulatory events
16. DC determine the outcome of T cell priming
17. CD11c^hi cells and induction of immunity in lungs
18. Depletion of pDCs during priming
19. Role of DCs in asthma?
20. Airway inflammation in chronic asthma
21. Th2 lymphocytes role in airway inflammation
22. DC and the Th2 response
23. DC role in allergic asthma
24. How could we target DCs?
25. Allergen exposure activation
26. House dust mite fecal pellets
27. Epithelial vs. DC expression of TLR4
28. Epithelial TLR4 role in allergic sensitisation
29. HDM driven inflammation and TLR4 antagonist
30. Metabolic alterations
31. Is uric acid released after HDM instillation?
32. Uric acid and HDM sensitisation in mice
33. Emerging model of Th2 sensitisation to HDM
34. DC role in secondary immune response (1)
35. DC role in secondary immune response (2)
36. Role of airway DCs during ongoing inflammation
37. DC depletion abolishes typical features of asthma
38. What is the function of DCs in chronic asthma?
39. Basement membrane thickening in asthma
40. Shielding off is similar to body reaction to parasite
41. Model of chronic airway remodelling in the lungs
42. Collagen deposition & antigen uptake/recognition
43. Antigen transport to MLN by DCs is enhanced
44. Remodelled lung DCs promote Th2 response
45. What happens if we present a neoantigen in vivo ?
46. Sensitisation to neoantigen is induced
47. Take home message
48. Acknowledgments

Topics Covered

• The global immune response of the lungs
• Dendritic cells (DCs): localisation, trafficking, probing for antigen, activation, behaviour in airways during asthma and inflammation
• Controlling responsiveness to the node T cell area & Immunological synapse formation
• Peptide presentation by MHC class II molecules
• Cascade of costimulatory events
• Th2 lymphocytes role in airway inflammation
• Targeting DCs
• Allergen exposure activation
• Epithelial vs. DC expression of TLR4
• Metabolic alterations
• Uric acid and antigen sensitisation in mice
• DC depletion
• Basement membrane thickening in asthma
• Model of chronic airway remodelling in the lungs
• Collagen deposition & antigen uptake/recognition
• Presentation of neoantigen

Links

Series:

• Advances in Asthma

Categories:

• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on September 22, 2013

Financial Disclosures

• Prof. Bart Lambrecht has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.