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- Introduction
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16 min
1. Psychopharmacology: structural aspects of the brain- Prof. Brian Leonard
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66 min
2. The nature of chemical neurotransmission- Prof. Brian Leonard
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28 min
3. Psychotropic drugs- Prof. Brian Leonard
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26 min
4. Psychopharmacology of anxiety disorders- Prof. Brian Leonard
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35 min
5. Psychopharmacology of depression- Prof. Brian Leonard
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48 min
6. Psychopharmacology of mania and schizophrenia- Prof. Brian Leonard
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45 min
7. The role of stress and immune system in psychiatric disorders- Prof. Brian Leonard
- Introduction to Genetic Investigations of Complex Traits
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39 min
- Genetics and Pharmacokinetics of Psychotropic Drugs
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34 min
9. Genetics of phase I enzymes- Prof. Aiming Yu
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36 min
10. Phase II metabolism- Prof. Ann Daly
- Genetics and Pharmacodynamics of Psychotropic Drugs
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25 min
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25 min
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52 min
13. Genetic polymorphisms influencing the response of antidepressants- Prof. Alessandro Serretti
- Clinical Applications of Psychopharmacogenetics
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41 min
14. Of genes and drugs: genetic determinants of adverse drug reactions- Dr. Mario Masellis
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35 min
15. Cocaine and amphetamine addiction genetics- Dr. Gerome Breen
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29 min
- Archived Lectures *These may not cover the latest advances in the field
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47 min
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37 min
18. Genetic determinants of metabolism: clinical applications in psychiatry- Prof. Julia Stingl (formerly Kirchheiner)
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36 min
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47 min
20. Genetic polymorphisms influencing response to lithium- Prof. Alessandro Serretti
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28 min
21. Genetic determinants of antipsychotic-induced weight gain- Prof. Gavin Reynolds
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59 min
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50 min
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37 min
24. Genetic determinants of agranulocytosis- Dr. Michael Dettling
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Background
- Structural information - genes and polymorphisms
- Outline: association at its simplest
- Association - example: snore gene
- Association - example: the data
- Association - example: Chi squared
- Odds ratio
- Hardy Weinberg equilibrium (HWE)
- HEW - calculation
- Quantitative
- Other issues
- Outline: LD and haplotypes
- Haplotypes
- Deriving haplotypes
- Deriving haplotypes with EM
- EM algoritum - example (1)
- EM algoritum - example (2)
- What is linkage disequilibrium?
- How does LD occur?
- LD illustration
- Measures of LD
- Outline: association with multiple marker
- Heterogeneity tests
- Regression with haplotypes: problem and solution
- Regression model
- Regression with haplotypes: the basics
- Regression with haplotypes: sub-tests example 1
- Regression with haplotypes: sub-tests example 2
- Improvements to haplotype analysis
- Outline: family based association
- Family based association
- TDT - example
- Outline: practicalities
- Programs
- Pedigree file
- Power calculations
- Me
Topics Covered
- Background of genetic studies
- Structure of a gene
- Simple association
- Linkage disequilibrium and haplotypes
- Multi-marker association
- Family-based association
- Practicalities of programs and power
Talk Citation
Knight, J. (2007, October 1). Genetic association studies, TDT and the candidate gene approach [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/261/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jo Knight has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Genetic association studies, TDT and the candidate gene approach
Published on October 1, 2007
39 min
