Printable Handouts

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Navigable Slide Index

1. Introduction
2. Outline
3. Background
4. Structural information - genes and polymorphisms
5. Outline: association at its simplest
6. Association - example: snore gene
7. Association - example: the data
8. Association - example: Chi squared
9. Odds ratio
10. Hardy Weinberg equilibrium (HWE)
11. HEW - calculation
12. Quantitative
13. Other issues
14. Outline: LD and haplotypes
15. Haplotypes
16. Deriving haplotypes
17. Deriving haplotypes with EM
18. EM algoritum - example (1)
19. EM algoritum - example (2)
20. What is linkage disequilibrium?
21. How does LD occur?
22. LD illustration
23. Measures of LD
24. Outline: association with multiple marker
25. Heterogeneity tests
26. Regression with haplotypes: problem and solution
27. Regression model
28. Regression with haplotypes: the basics
29. Regression with haplotypes: sub-tests example 1
30. Regression with haplotypes: sub-tests example 2
31. Improvements to haplotype analysis
32. Outline: family based association
33. Family based association
34. TDT - example
35. Outline: practicalities
36. Programs
37. Pedigree file
38. Power calculations
39. Me

Topics Covered

• Background of genetic studies
• Structure of a gene
• Simple association
• Linkage disequilibrium and haplotypes
• Multi-marker association
• Family-based association
• Practicalities of programs and power

Links

Series:

• Psychopharmacogenetics

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Knight, J. (2007, October 1). Genetic association studies, TDT and the candidate gene approach [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/SGVQ8739.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Jo Knight has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.