Waagepetersen, H. (2013, August 19). Energy and amino acid neurotransmitter metabolism in astrocytes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 21, 2024, from https://hstalks.com/bs/2604/.
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Published on August 19, 2013
Prof. Helle Waagepetersen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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My name is
Helle Waagepetersen.I'm the head of the
NeuroMetabolism Research Unit,and Department of Drug
Design and Pharmacologyof the University of Copenhagen.The title of my talk is
"Energy and Amino AcidNeurotransmitter
Metabolism in Astrocytes."
Astrocytes are central in the
maintenance of particularlyglutamate homeostasis in
the brain, but they are alsoessential players in
brain energy metabolism.The first part of my talk will
focus on glutamate homeostasis,shuttling the metabolites
between neurons and astrocytes,and glutamate metabolism
in astrocytes.I will cover the
Glutamate-Glutamine cycle,with focus on carbon homeostasis,
and nitrogen homeostasis,also anaplerosis and
de-novo glutamine synthesis.And next glutamate oxidation,
focusing on mitochodrial transportand metabolism, the
truncated TCA-cycle, GDH,and pyruvate recycling.And some experimental
guidance, how to investigateglutamate metabolism.The second part of my talk will
be on how astrocytes are involvedin energy metabolism,
as lactate transferredbetween neurons and
astrocytes, and glycogen.This is an essential energy source,
which is coupled to brain function.
Glutamate is released from
the presynaptic neuron,and interacts with
postsynaptic receptors,and diffuses away from
the synaptic cleft,with the surrounding
astrocytes, which are equippedwith an efficient machinery to
take up glutamate, primarilyvia the high affinity glutamate
transporters, GLT1 and GLAST.
Neurons do not have the
appropriate enzymatic machineryto provide anaplerosis, meaning
de-novo synthesis of glutamatefrom the precursor glucose.Thus, glutamate that is
taken up by the astrocyteneeds to be returned to the neuron.