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1. Introduction
2. Enteric glial cells
3. Acknowledgements (1)
4. The gastrointestinal (GI) tract
5. Digestion is a dangerous process
6. Enteric nervous system (ENS)
7. The anatomy of the ENS
8. The gut and its brain
9. Enteric glia - discovery
10. Enteric glia
11. Neuroglial junctions
12. Enteric glia surround enteric neurons (1)
13. Enteric glia surround enteric neurons (2)
14. Enteric glia surround enteric neurons (3)
15. Four types of enteric glia in the gut wall (1)
16. Four types of enteric glia in the gut wall (2)
17. Mucosal enteric glia
18. Mucosal enteric glia: epithelial barrier function (1)
19. Mucosal enteric glia: epithelial barrier function (2)
20. Mucosal enteric glia: epithelial barrier function (3)
21. Mucosal enteric glia & burn injury
22. Epithelial cell differentiation and proliferation (1)
23. Epithelial cell differentiation and proliferation (2)
24. Intraganglionic enteric glia
25. Enteric glia “listen” to enteric nerves (1)
26. Enteric glia “listen” to enteric nerves (2)
27. Evidence for mGluR5 activation
28. Calcium imaging to visualize activity in enteric glia
29. ATP stimulates enteric glia in situ (1)
30. ATP stimulates enteric glia in situ (2)
31. Do enteric glia respond to neuronal activity?
32. Glial Ca2+ responses in situ (1)
33. Glial Ca2+ responses in situ (2)
34. Neurons directly activate glial cells
35. Enteric glia express P2Y4 and not P2Y11
36. Summary (1)
37. Selectivity to glial cell activation
38. Neuronal component(s) “talk” to glia
39. Enteric glia detect activity in neural pathways
40. Nicotinic stimulation of enteric neurons
41. Myenteric P2X7 expression and function
42. P2X7 neuron-to-glia communication (1)
43. P2X7 neuron-to-glia communication (2)
44. Glial ectonucleotidases regulate responses
45. Pannexin-1 channels
46. Neurons release ATP via pannexin-1 channels
47. Enteric glia monitor extracellular purines
48. Enteric glia and colonic migrating motor complex
49. Functional glial ablation
50. Gliogenesis and neurogenesis
51. Gliogenesis in the ENS
52. GFAP expression is enhanced in colitis
53. Neurogenesis
54. Summary (2)
55. Functional subpopulation of enteric glia
56. Enteric glia – key points
57. Acknowledgements (2)
58. References

Topics Covered

• The gut and its brain
• Anatomy and distribution of enteric glia
• Mucosal enteric glia
• Intraganglionic enteric glia
• Gliogenesis and neurogenesis

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 20, 2013

Financial Disclosures

• Dr. Keith A. Sharkey has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.