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34 min
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37 min
2. Diabetes through the ages- Dr. Michael Stephen Hall
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35 min
3. Evolution of diagnostic criteria for diabetes- Prof. Mayer Davidson
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40 min
4. Diagnosis and screening of diabetes- Prof. Jonathan Shaw
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53 min
5. The treatment of type 1 diabetes in children and youth- Prof. Francine Kaufman
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37 min
6. What is new in type 1 diabetes?- Prof. Åke Lernmark
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33 min
7. Autoimmune diabetes in adults: current evidence and controversies- Prof. Richard David Leslie
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52 min
8. Type 2 diabetes- Prof. Edward Boyko
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27 min
9. Inflammation in type 2 diabetes and associated disease- Prof. Marc Y. Donath
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29 min
10. Pre-gestational diabetes and pregnancy- Prof. Jeremy J. N. Oats
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37 min
11. Understanding and managing gestational diabetes- Prof. Jeremy J. N. Oats
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29 min
12. Gene-environment interactions in complex disease- Prof. Paul Franks
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42 min
13. Diabetes and heart disease- Prof. Trevor J. Orchard
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46 min
14. The eye and diabetes- Prof. Tien Wong
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61 min
15. The metabolic syndrome- Prof. Jean Pierre Després
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44 min
16. Physical activity, sedentary behavior and diabetes- Prof. David Dunstan
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72 min
17. Cardiovascular prevention in type 2 diabetes- Prof. Eberhardt Standl
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48 min
18. Economic and social cost of diabetes- Dr. Ping Zhang
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32 min
19. Diabetes biomarkers- Prof. Naveed Sattar
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44 min
20. Type 1 diabetes: control and complications trials- Prof. John Petrie
- Archived Lectures *These may not cover the latest advances in the field
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31 min
21. Latent autoimmune diabetes in adults- Prof. Richard David Leslie
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25 min
22. Inflammation and type 2 diabetes- Prof. Marc Y. Donath
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41 min
23. What is new in type 1 diabetes?- Prof. Åke Lernmark
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46 min
24. Diabetes through the ages- Dr. Michael Stephen Hall
Printable Handouts
Navigable Slide Index
- Introduction
- Acknowledgments
- Type 1 Diabetes
- Classic view of type 1 diabetes
- Autoimmune disease: a minimal model
- Age at diagnosis of autoimmune diabetes
- Type 1 diabetes associated genes
- Evidence for non-genetic effects
- Type 1 diabetes in identical twins
- Evidence for non-genetic effects: MZ twins
- Minimal model - tissue inflammation
- Early induction of islet cell antibodies
- Multiple islet autoantibodies role in the disease
- Minimal model - events occur before inflammation
- Serum CML in a general population
- An AGE predicts autoimmune diabetes
- Serum biomarkers for autoimmune diabetes
- Minimal model - events occur after inflammation
- Type 1 diabetes is not acute
- Adult-onset autoimmune diabetes
- GADA positive patients (LADA)
- GADA is the dominant autoantibody in LADA
- Adult-onset autoimmune diabetes (2)
- Autoimmune type 1 diabetes
- IL-6 in LADA
- Inflammation and diabetes
- Peak value of C-peptide as a function of age
- Action LADA metabolic syndrome
- Autoimmune diabetes spectrum
- Challenging the classical view of type 1 diabetes
Topics Covered
- Autoimmunity is induced in early life
- Autoimmunity involves non-genetic effects which occur in childhood
- At least 2 non-genetic effects are involved in predisposing to type 1 diabetes
- The age at which autoimmune diabetes is diagnosed affects the clinical and immunogenetic pattern of the disease
- Autoimmune diabetes in adults in Europe as in China is the most prevalent form of autoimmune diabetes
Links
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Talk Citation
Leslie, R.D. (2013, May 22). Latent autoimmune diabetes in adults [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 2, 2025, from https://doi.org/10.69645/DYVK1356.Export Citation (RIS)
Publication History
Financial Disclosures
- The speaker sits on the advisory board for Abbott, Sanofi, Roche, Novo-Nordisk and Diamyd. He receives funding from the EU, EFSD, Barts Charity and Diabetic Twin Trust.
